Results 91 to 100 of about 209,221 (295)
Overcoming restrictive technologies in police call centres: A human agency perspective
, 2008 Call centres in the police force are restrictive information systems which tend to present call operators with constraints that they need to overcome using their experience in order to offer better services to the public.
Spinelli, G +2 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Whitehead's Theory of Human Agency
, 1964 An adequate theory of the self must provide for the fact of human agency. I would like to show that (1) we can put together a theory of human agency from Whitehead's later writings, but that (2) this theory is not satisfactory.
Douglas Browning
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ECONOMIC ANALYSIS OF HIRING FORMS DEDICATED TO MANAGERIAL POSITIONS IN POLAND
Ekonomia i Prawo, 2015 This paper deals with the economic analysis of hiring forms dedicated to managerial positions. Theoretical frames for corporate governance are based on agency theory.
Jacek Lewkowicz
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Webscience, 'social machines' and principles for redesigning theories of agency: a prolegomenon
, 2013 This paper argues that the advent of the WWW and the principles now developing for the move ‘social machines’ has posed serious challenges to traditional social theory.
Vass, J.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Agency Theory and the Internal Audit
, 1994 Agency theory is extensively employed in the accounting literature to explain and predict the appointment and performance of external auditors. Argues that agency theory also provides a useful theoretical framework for the study of the internal auditing ...
Michael B. Adams
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THE APPROACH OF AGENCY THEORY AND THE RELATIONSHIP BETWEEN TRANSACTION COST
Sakarya Üniversitesi İktisat Dergisi, 2014 Agency theory is a concept which appears quite a lot of in modern companies. Especially in multi-partner companies and enterprises, there is a proxy noble problems and in organizations this cause transaction costs.In this study, this relationship will be
Neriman Çelik, Aykut Bedük
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source