Results 111 to 120 of about 6,568,437 (291)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Texas Education Agency Annual Report
, 2017 Annual report describing the Texas Education Agency's strategic plan, recruit, support and retain teachers and principals, build a foundation of reading and math, connect high school to career and college, improve low-performing schools, enrollment and ...
Texas Education Agency
core
The Agency Theory Applied to the Investment Funds
BBR: Brazilian Business Review, 2004 This article seeks to verify the existence of a relationship between the rate of remuneration charged by the administrators of investment funds and the profitability of these portfolios, under the perspective of the Agency Theory. The Agency Theory seeks
Flávia Zóboli Dalmácio +1 more
doaj
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Report: Jewish Agency Settlement Department, The Industrial Village, July 1974
, 1974 Textual: Report; staple holes, 11" x 8.5" (29.7 cm x 21.6 cm)Report from the Jewish Agency Settlement Department entitled "The Industrial Village: A New Form of Settlement… A New Form of Opportunity for Aliyah" from 1974. This report discusses a new form
Jewish Agency Settlement Department
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
USIA, The United States Information Agency Homepage
, 1999 An independent foreign affairs agency supporting U.S. foreign policy and national interests abroad, USIA conducts international educational and cultural exchanges, broadcasting, and information ...
United States Information Agency
core
Texas Education Agency Annual Report
, 2021 The Texas Education Agency released its 2020 Annual Report to the general public. The report shine light on the TEA commitment to ensuring that every one of the more than five million public school students in Texas is prepared for success in college, a ...
Texas Education Agency
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source