Results 41 to 50 of about 209,221 (295)
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
This study aims to criticize the causal relationship between agency theory and GONE theory with Habermas's radical humanist paradigm. Qualitative research methods and in-depth interviews with informants were used in this study.
Nanang Shonhadji
doaj +1 more source
Despite the long history of testing agency theory, it is yet standing undefeated. This study examines the relationship between capital structure and firm performance in an emerging economy, Iraq.
Shirwan Rafiq Sdiq, Hariem A. Abdullah
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
This study examines the relationship between capital structure (DER), company size, and corporate governance (GCG) on company performance with a mediating variable in the form of agency costs.
Kurniawati D., Yatna C.N.
doaj +1 more source
Explanation and Criticism of Moral Agency in Social Cognitive Learning Theory1 [PDF]
Morality is one of the most dominant educational domains that is correspondent on human agency. Because requests responsibility about moral acting or disengagement. For knowing how to apply education in moral fild, it is nessesery being illustrate agency
Zahra Ashari, Mohammad Hasani
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Overviews Of Contracting Theory & Agency Theory: Determinants Public Accounting Firms Switching On Voluntary [PDF]
This study is a literature study to explore research related to factors affecting the voluntary the Public Accounting Firm (PAF) switching, in terms of contract theory associated with the agency theory stated by Watts & Zimmerman (1986).
Subroto, Bambang +3 more
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