Results 61 to 70 of about 6,568,437 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Overviews Of Contracting Theory & Agency Theory: Determinants Public Accounting Firms Switching On Voluntary [PDF]

, 2019
This study is a literature study to explore research related to factors affecting the voluntary the Public Accounting Firm (PAF) switching, in terms of contract theory associated with the agency theory stated by Watts & Zimmerman (1986).
Subroto, Bambang, Subekti, Imam, Rahman, Aulia Fuad, Safriliana, Retna   +3 more
core  

The problem of unilateralism in agency theory: towards a bilateral formulation [PDF]

, 2017
Some business ethicists view agency theory as a cautionary tale – a proof that it is impossible to carry out successful economic interactions in the absence of ethical behaviour.
Frooman, Jeff, Sareh Pouryousefi, Jeff Frooman, Pouryousefi, Sareh   +3 more
core   +1 more source

Theory-Praxis: Principals vs. Agents among Namibian Public Enterprises

iRASD Journal of Management
In Namibia, public enterprise (PE) agents are obligated to prioritize and advance the interests of their principals (namely the government). However, recent trends have seen the proliferation of conflicts arising due to impediments such as information ...
Ralph Marenga
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Texas Education Agency Annual Report

, 2020
The report describe the Texas Education Agency strategic plan, recruit, support and retain teachers and principals, build a foundation of reading and math, connect high school to career and college, improve low-performing schools, enrollment and ...
Texas Education Agency
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The sensitivity of corporate social performance to corporate financial performance: A “time-based” agency theory perspective

, 2020
This study focuses on micro-level phenomena and time issues that have been traditionally neglected in both corporate governance and corporate social responsibility research. Drawing on agency theory concerning time-based managerial incentives (i.e. short
Park, Bum-Jin, Lee, Ki-Hoon
core   +1 more source