Results 91 to 100 of about 777,631 (313)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Workshop on Agent-Based Modeling [PDF]
, 2007 After the success of the first workshop of Agent-based approach in Economic and Social Complex Systems (AESCS) in Shimane, 2001, we have held a similar workshop in Niigata, 2003. The title is International Workshop on Agent-Based Modeling. The aims and scope are summarized as follows: Agent-Based Modeling has become one of major techniques to design ...
openaire +1 more source
Agent-Based Modeling: The Right Mathematics for the Social Sciences? [PDF]
This study provides a basic introduction to agent-based modeling (ABM) as a powerful blend of classical and constructive mathematics, with a primary focus on its applicability for social science research. The typical goals of ABM social science ...
Tesfatsion, Leigh, Borrill, Paul L.
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Data & PolicyEffective enforcement of laws and regulations hinges heavily on robust inspection policies. While data-driven approaches to testing the effectiveness of these policies are gaining popularity, they suffer significant drawbacks, particularly a lack of ...
Eunice Koid +2 more
doaj +1 more source
A Survey of Agent-Based Modeling Practices (January 1998 to July 2008) [PDF]
In the 1990s, Agent-Based Modeling (ABM) began gaining popularity and represents a departure from the more classical simulation approaches. This departure, its recent development and its increasing application by non-traditional simulation disciplines ...
Brian Heath +2 more
core
Agent-Based Modeling of Microbial Communities
, 2022 Microbial communities are complex living systems that populate the planet with diverse functions and are increasingly harnessed for practical human needs.
Ting Lu (149031) +2 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Decentralized Solution for Transmission Expansion Planning: Getting Inspiration from Nature
Energies, 2019 Transmission expansion planning is a problem of considerable complexity where classical optimization techniques are unable to handle large case studies. Decomposition and divide-and-conquer strategies have been applied to this problem.
Sara Lumbreras +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source