Results 71 to 80 of about 777,631 (313)
Agent-based modeling: A revolution? [PDF]
Proceedings of the National Academy of Sciences, 2002 A clear consensus among the papers in this Colloquium is that agent-based modeling is a revolutionary development for social science. However, the reasons to expect this revolution lie more in the potential seen in this tool than through realized results. In order for the anticipated revolution to occur, a series of challenges must be met.
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An Agent-Based Approach to Immune Modelling [PDF]
, 2006 This study focuses on trying to understand why the range of experience with respect to HIV infection is so diverse, especially as regards to the latency period. The challenge is to determine what assumptions can be made about the nature of the experience of antigenic invasion and diversity that can be modelled, tested and argued plausibly.
Perrin, Dimitri +3 more
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Platforms and methods for agent-based modeling [PDF]
Proceedings of the National Academy of Sciences, 2002 The range of tools designed to help build agent-based models is briefly reviewed. It is suggested that although progress has been made, there is much further design and development work to be done. Modelers have an important part to play, because the creation of tools and models using those tools proceed in a dialectical relationship.
Gilbert, Nigel, Bankes, Steven
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Agent-Based Model of Genotype Editing
Evolutionary Computation, 2007 Evolutionary algorithms rarely deal with ontogenetic, non-inherited alteration of genetic information because they are based on a direct genotype-phenotype mapping. In contrast, several processes have been discovered in nature which alter genetic information encoded in DNA before it is translated into amino-acid chains. Ontogenetically altered genetic
Chien-Feng Huang +3 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Transportation in Agent-Based Urban Modelling [PDF]
, 2017 As the urban population rapidly increases to the point where most of us will be living in cities by the end of this century, the need to better understand urban areas grows ever more urgent. Urban simulation modelling as a field has developed in response to this need, utilising developing technologies to explore the complex interdependencies, feedbacks,
Sarah Wise +2 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Agent-based conceptual model representation using BPMN [PDF]
, 2011 In a simulation project, a good conceptual model representation is critical for communicating conceptual models between stakeholders. A conceptual model describes the problem domain and model specifications. The description of the problem domain includes
Onggo, Stephan +4 more
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