Results 71 to 80 of about 694,255 (290)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Specification and Verification of Commitment-Regulated Data-Aware Multiagent Systems [PDF]

, 2014
In this paper we investigate multi agent systems whose agent interaction is based on social commitments that evolve over time, in presence of (possibly incomplete) data.
DE GIACOMO, Giuseppe, Diego, Calvanese, Marco, Montali   +2 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A novel approach to model the role of mobility suppression and vaccinations in containing epidemics in a network of cities

Infectious Disease Modelling
This paper presents a comprehensive agent-based model for the spread of an infection in a network of cities. Directional mobility is defined between each two cities and can take different values.
Leen Alrawas, Abdessamad Tridane, Ghassane Benrhmach   +2 more
doaj   +1 more source

Logic-Based Specification Languages for Intelligent Software Agents

, 2003
The research field of Agent-Oriented Software Engineering (AOSE) aims to find abstractions, languages, methodologies and toolkits for modeling, verifying, validating and prototyping complex applications conceptualized as Multiagent Systems (MASs). A very
Martelli, Maurizio, Mascardi, Viviana, Sterling, Leon   +2 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Unrecognized Death Toll of COVID-19 in the United States

The Lancet Regional Health. Americas, 2021
Seyed M. Moghadas, Alison P. Galvani
doaj   +1 more source

Pedestrian Attribute Analysis Using Agent-Based Modeling

Applied Sciences, 2020
Crossing a road outside of a crosswalk is a major cause of pedestrian fatalities. The aim of this study was to investigate this type of behavior for different pedestrian attributes in terms of risk and gap acceptance using agent-based modeling techniques.
Khaled Shaaban, Karim Abdelwarith
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source