Results 41 to 50 of about 694,255 (290)

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Integrating artificial intelligence with mechanistic epidemiological modeling: a scoping review of opportunities and challenges

Nature Communications
Integrating prior epidemiological knowledge embedded within mechanistic models with the data-mining capabilities of artificial intelligence (AI) offers transformative potential for epidemiological modeling.
Yang Ye, Abhishek Pandey, Carolyn Bawden, Dewan Md. Sumsuzzman, Rimpi Rajput, Affan Shoukat, Burton H. Singer, Seyed M. Moghadas, Alison P. Galvani   +8 more
doaj   +1 more source

THE ROLE OF AGENT-BASED MODELING AND COMPUTER SIMULATIONS IN POLITICAL SCIENCE

Вісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології", 2023
It considers opportunities for using computer agent-based modeling in studies related to political process analyses. Gives information about the historical context of computer simulation based on agent model implementation, and emphasizes the ...
Oleksandr Chornenkyi
doaj   +1 more source

Agent-Based Modeling of Pollen Competition [PDF]

, 2018
Non-random mating in Arabidopsis Thaliana is, at least in part, due to intense competition between pollen grains to fertilize the limited number of ovules.
Bassett, Katherine
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Introduction of a framework for dynamic knowledge representation of the control structure of transplant immunology: employing the power of abstraction with a Solid Organ Transplant Agent-based Model (SOTABM)

Frontiers in Immunology, 2015
Agent-based modeling has been used to characterize the nested control loops and nonlinear dynamics associated with inflammatory and immune responses, particularly as a means of visualizing putative mechanistic hypotheses.
Gary eAn
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Assessing the impact of revising MenACWY vaccination schedule for adolescents in the United States: a modelling studyResearch in context

The Lancet Regional Health. Americas
Summary: Background: The current recommendation for MenACWY vaccination against invasive meningococcal disease (IMD) in the United States (US) includes two doses: the first dose at ages 11–12 and a booster dose at age 16.
Affan Shoukat, Chad R. Wells, Thomas Shin, Lilia Potter-Schwartz, Alison P. Galvani, Seyed M. Moghadas   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source