Results 121 to 130 of about 459,186 (346)

The Unrecognized Death Toll of COVID-19 in the United States

open access: yesThe Lancet Regional Health. Americas, 2021
Seyed M. Moghadas, Alison P. Galvani
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

AN ALGEBRA FOR MODELLING THE SIMULTANEITY IN AGENTS' BEHAVIOR IN SPATIALLY EXPLICIT SOCIAL-ENVIRONMENTAL MODELS

open access: yesRevista Brasileira de Cartografia, 2017
Humanity is the major driver of spatial changes resulting from interactions between social and environmental systems. Environmental models usually apply the agent-based modeling paradigm to describe the social aspects of spatial changes. For this reason,
Washington Sena de Franca Silva   +1 more
doaj  

A review of Multi-Agent Simulation Models in Agriculture [PDF]

open access: yes
Multi-Agent Simulation (MAS) models are intended to capture emergent properties of complex systems that are not amenable to equilibrium analysis. They are beginning to see some use for analysing agricultural systems. The paper reports on work in progress
Kaye-Blake, William   +5 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Simulating Knowledge-Generation and -Distribution Processes in Innovation Collaborations and Networks [PDF]

open access: yes
An agent-based simulation model representing a theory of the dynamic processes involved in innovation in modern knowledge-based industries is described. The agent-based approach al-lows the representation of heterogeneous agents that have individual and ...
Andreas Pyka   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

A Pragmatic Reading of Friedman's Methodological Essay and What It Tells Us for the Discussion of ABMs [PDF]

open access: yes
The issues of empirical calibration of parameter values and functional relationships describing the interactions between the various actors plays an important role in agent based modelling.
Andreas Pyka, Simon Deichsel
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Epidemiological Agent-Based Modelling Software (Epiabm)

open access: yesJournal of Open Research Software
Epiabm is an open-source software package for epidemiological agent-based modelling, re-implementing the well-known CovidSim model from the MRC Centre for Global Infectious Disease Analysis at Imperial College London. It has been developed as part of the
Kit Gallagher   +9 more
doaj   +1 more source

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