Results 141 to 150 of about 459,186 (346)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Aid Competition – a Simple Agent-Based Model of Competition for Financial Aid

Interdisciplinary Description of Complex Systems, 2007
The research into the effectiveness of financial aid is gaining momentum lately. Some say it is ineffective, some say it could be effective, but all seem to agree that some of its aspects are currently unmapped.This article aims at showing a rather ...
András Margitay-Becht
doaj  

A framework for building conversational agents based on a multi-expert model [PDF]

, 2008
Mikio Nakano, Kotaro Funakoshi, Yuji Hasegawa, Hiroshi Tsujino   +3 more
openalex   +1 more source

Is Your Model Susceptible to Floating-Point Errors? [PDF]

This paper provides a framework that highlights the features of computer models that make them especially vulnerable to floating-point errors, and suggests ways in which the impact of such errors can be mitigated.
J. Gary Polhill, Luis R. Izquierdo
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Statistical properties of agent-based models in markets with continuous double auction mechanism

, 2010
Jie-Jun Tseng, Chih-Hao Lin, Chih‐Ting Lin, Sun-Chong Wang, Sai-Ping Li   +4 more
openalex   +1 more source

ABMQ: An Agent-Based Modeler and Simulator for Self-Organization in MANETs using Qt [PDF]

, 2013
Mohammad Noormohammadpour, Mohammad Javad Salehi, Seyed Mohammad Asghari Pari, Babak Hossein Khalaj, Hamidreza Bagheri, Marcos Katz   +5 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Mechanisms of Self-Organization and Finite Size Effects in a Minimal Agent Based Model

, 2008
V. Alfi, Matthieu Cristelli, L. Pietronero, Andrea Zaccaria   +3 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source