Results 151 to 160 of about 431,918 (275)

Using Qualitative Evidence to Enhance an Agent-Based Modelling System for Studying Land Use Change [PDF]

This paper describes and evaluates a process of using qualitative field research data to extend the pre-existing FEARLUS agent-based modelling system through enriching its ontological capabilities, but without a deep level of involvement of the ...
J. Gary Polhill, Lee-Ann Sutherland, Nicholas M. Gotts   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Learning about unprecedented events: Agent-based modelling and the stock market impact of COVID-19. [PDF]

Financ Res Lett, 2023
Bazzana D, Colturato M, Savona R.
europepmc   +1 more source

The agricultural policy simulator (AgriPoliS): an agent-based model to study structural change in agriculture (Version 1.0) [PDF]

A central criticism common to agricultural economic modelling approaches for policy analysis is that they do not adequately take account of a number of characteristic factors of the agricultural sector.
Balmann, Alfons, Happe, Kathrin, Kellermann, Konrad   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigating immersion and migration decisions for agent-based modelling: A cautionary tale. [PDF]

Open Res Eur, 2023
Bijak J, Modirrousta-Galian A, Higham PA, Prike T, Hinsch M, Nurse S.   +5 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Studying COVID-19 transmission in US state prisons using an agent-based modelling approach: a simulation study. [PDF]

BMJ Open
Owens AL, Fliss M, Brinkley-Rubinstein L.   +2 more
europepmc   +1 more source

Agent-Based Modelling of Health Inequalities following the Complexity Turn in Public Health: A Systematic Review. [PDF]

Int J Environ Res Public Health, 2022
Boyd J, Wilson R, Elsenbroich C, Heppenstall A, Meier P.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source