Results 31 to 40 of about 35,468,233 (307)

Cooperative behavior in pre-state societies: an agent based approach to the Axum civilization

Frontiers in Complex Systems
IntroductionThis study intends to test the hypothesis that, contrary to traditional interpretation, the social structure of the polity of Aksum–especially in its early stages–was not characterized by a vertical hierarchy with highly centralized ...
Riccardo Vasellini, Riccardo Vasellini, Gilda Ferrandino, Luisa Sernicola, Daniele Vilone, Daniele Vilone, Chiara Mocenni   +6 more
doaj   +1 more source

Going beyond BDI for agent-based simulation

Journal of Information and Telecommunication, 2019
Research in multi-agent systems has resulted in agent programming languages and logics that are used as a foundation for engineering multi-agent systems.
John Bruntse Larsen
doaj   +1 more source

Functional balance at rest of hemispheric homologs assessed via normalized compression distance

Frontiers in Neuroscience
IntroductionThe formation and functioning of neural networks hinge critically on the balance between structurally homologous areas in the hemispheres. This balance, reflecting their physiological relationship, is fundamental for learning processes.
Annalisa Pascarella, Vittoria Bruni, Vittoria Bruni, Karolina Armonaite, Camillo Porcaro, Camillo Porcaro, Camillo Porcaro, Livio Conti, Federico Cecconi, Luca Paulon, Luca Paulon, Domenico Vitulano, Franca Tecchio   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Novice, the Expert, and the Algorithm: A Comparative Analysis of Human Expertise Transfer and AI Performance in Audio-Only Gaming Environments

Applied Sciences
This study provides a symmetrical, cross-genre comparison of human expertise transfer and “blind” artificial intelligence (AI) performance in audio-only gaming environments.
Ibrahim Khan, Thai Van Nguyen, Cvetković Tijan Juraj, Ruck Thawonmas   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

AN INTRODUCTION TO AGENT BASED MODELLING AND SIMULATION OF SOCIAL PROCESSES [PDF]

Interdisciplinary Description of Complex Systems, 2003
The paper provides an introduction to agent-based modelling and simulation of social processes. Reader is introduced to the worldview underlying agent-based models, some basic terminology, basic properties of agent-based models, as well as to what one ...
Ognjen Skunca, Armano Srbljinovic
doaj  

Is there a Need for Agent-based Modelling and Simulation in Business Process Management?

Organizacija, 2018
Background and Purpose: Agent-based modelling and simulation (ABS) is growing in many areas like, e.g., management, social and computer sciences. However, the similar trend does not seem to occur within the field of business process management (BPM ...
Halaška Michal, Šperka Roman
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source