Results 91 to 100 of about 831,999 (267)
Frontiers in Built EnvironmentGlobally, high-speed rail systems serve nearly 2 billion passenger-km daily. By virtue, they are a critical infrastructure like telecommunication and power networks.
Pattrapon Kongsap, Sakdirat Kaewunruen
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EAI Endorsed Transactions on Context-aware Systems and Applications, 2017 Modeling in ecology or epidemiology generally opposes two classes of models, Equation Based Models and Agent Based Models. Mathematical models allow predicting the long-term dynamics of the studied systems. However, the variability between individuals is
Nghi Quang Huynh +4 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
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Agent-based conceptual development and optimization based on a genetic algorithm in water resource allocation [PDF]
علوم محیطی, 2018 Introduction: In water resource allocation, a good division is a major principle which is difficult to determine due to the existence of different criteria.
Amin Hosseiniasl +2 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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An Agent-based Model for the Humanities
Digital Humanities Quarterly, 2013 The Humanities now confront a new era in cultural representations — the digital age. As a consequence, our approach to culture may be modified because technology allows us to now visualize our thoughts and theories using digital and computing techniques.
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