Results 71 to 80 of about 2,509,130 (293)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A Multi Agent Based Model for Airport Service Planning
International Journal of Engineering Business Management, 2010 Aviation industry is highly dynamic and demanding in nature that time and safety are the two most important factors while one of the major sources of delay is aircraft on ground because of it complexity, a lot of machinery like vehicles are involved and ...
W.H. Ip +3 more
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Data & Policy, 2020 We build a computational framework to support the planning of development and the evaluation of budgetary strategies toward the 2030 Agenda. The methodology takes into account some of the complexities of the political economy underpinning the ...
Omar A. Guerrero, Gonzalo Castañeda
doaj +1 more source
Agent-Based Model of Genotype Editing
Evolutionary Computation, 2007 Evolutionary algorithms rarely deal with ontogenetic, non-inherited alteration of genetic information because they are based on a direct genotype-phenotype mapping. In contrast, several processes have been discovered in nature which alter genetic information encoded in DNA before it is translated into amino-acid chains. Ontogenetically altered genetic
Chien-Feng Huang +3 more
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
An Agent-based Route Choice Model [PDF]
Travel demand emerges from individual decisions. These decisions, depending on individual objectives, preferences, experiences and spatial knowledge about travel, are both heterogeneous and evolutionary. Research emerging from fields such as road pricing
David Levinson, Lei Zhang, Shanjiang Zhu
core
A Methodology to Engineer and Validate Dynamic Multi-level Multi-agent Based Simulations
, 2013 This article proposes a methodology to model and simulate complex systems, based on IRM4MLS, a generic agent-based meta-model able to deal with multi-level systems.
C. Chen +9 more
core +1 more source
Model Based Testing for Agent Systems
International Joint Conference on Autonomous Agents and Multiagent Systems, 2008 The use of agent technology for building complex systems is increasing, and there are compelling reasons to use this technology. Benfield [1] showed a productivity gain of over 300% using a BDI (Belief Desire Intention) agent approach, while other work calculated that a very modest plan and goal structure provides well over a million ways to achieve a ...
Zhiyong Zhang +2 more
openaire +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source