Results 81 to 90 of about 7,808,879 (322)

Simulating Historical Communication Networks in Python

The Programming Historian
This lesson will introduce the core concepts, methodologies and discussions surrounding simulation methods for historical inquiry. You will learn the basics of programming a simulation model by building an Agent-Based Model of historical letter exchanges
Jascha Schmitz, Malte Vogl, Aleksandra Kaye, Raphael Schlattmann   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Application of Agent Based Modeling in the Analysis of Complex Social Systems: The Methodology of Innovation Systems Analysis [PDF]

سیاست نامه علم و فناوری, 2018
The main purpose of this Article is to describe the methodology of complex social systems with focused on analysis of innovation systems. At this paper, we analyze innovation system as a complex system and then, try to describe the best methodology for ...
Saeed Roshany
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigating Impact of Intelligent Agents in Improving Supply Chain Performance

International Journal of Industrial Engineering and Production Research, 2011
Improvement in supply chain performance is one of the major issues in the current world. Lack of coordination in the supply chain is the main drawback of supply chain that many researchers have proposed different methodologies to overcome it. VMI (Vendor-
F Etebari, M. Abedzadeh, F. Khoshalhan
doaj  

Multi-agent quality of experience control [PDF]

, 2017
In the framework of the Future Internet, the aim of the Quality of Experience (QoE) Control functionalities is to track the personalized desired QoE level of the applications.
DELLI PRISCOLI, Francesco, DI GIORGIO, Alessandro, Lisi, Federico, Monaco, Salvatore, Pietrabissa, Antonio, RICCIARDI CELSI, Lorenzo, Suraci, Vincenzo   +6 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Evaluating methodologies: a requirements engineering approach through the use of an exemplar

Journal of Computer Science and Technology, 2005
Systems development methodologies continue to be a central area of research in software engineering. As the nature of applications and systems usage move increasingly towards open networked environments, not only are new methodologies required, but new ...
Luiz Marcio Cysneiros, Vera Werneck, Eric Yu   +2 more
doaj  

StarGro: Building i* metrics for agile methodologies [PDF]

, 2014
Requirements management is one of the cornerstone activities in software development. Agile methodologies use dedicated methods, techniques and artifacts in order to implement this activity.
Colomer, Daniel, Franch Gutiérrez, Javier   +1 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source