Results 61 to 70 of about 540,903 (278)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Bromometric Estimation of Gliclazide and Glibenclamide in Bulk and in tablet Formulation

Zagazig Journal of Pharmaceutical Sciences, 2015
Two spectrophotometric methods described for determination of, Gliclazide and Glibenclamide in bulk and pharmaceutical dosage forms using insitu generated bromine as oxidizing agent and either methylene blue or methyl orange as chromogenic agents.
Mohammed M. Amin , Sobhy M. El-Adl , Salah A. Abdel-Aziz , Samia M. Mostafa   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Logic-Based Specification Languages for Intelligent Software Agents

, 2003
The research field of Agent-Oriented Software Engineering (AOSE) aims to find abstractions, languages, methodologies and toolkits for modeling, verifying, validating and prototyping complex applications conceptualized as Multiagent Systems (MASs). A very
Martelli, Maurizio, Mascardi, Viviana, Sterling, Leon   +2 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Microstructure of PDA/PVDF ultrafiltration membranes under two pore-forming agents and comparison of their retention of organic dyes

Xi'an Gongcheng Daxue xuebao
In order to improve the pollution resistance of polyvinylidene fluoride (PVDF) ultrafiltration membrane to organic dyes, PVDF modified ultrafiltration membrane (PDA/PVDF membrane) was prepared by phase transformation method using polydopamine (PDA) as ...
YANG Jing, WANG Zhexi, HAN Dandan, ZHAI Yingjian, YUAN Ao   +4 more
doaj   +1 more source

Preference fusion and Condorcet's Paradox under uncertainty [PDF]

, 2017
Facing an unknown situation, a person may not be able to firmly elicit his/her preferences over different alternatives, so he/she tends to express uncertain preferences.
belnap, de caritat, elarbi, lacroix, marden, martin, schubert, shafer, smets, wellman, öztürké   +10 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Genome-wide identification and expression analysis of the MADS gene family in sweet orange (Citrus sinensis) infested with pathogenic bacteria [PDF]

PeerJ
The risk of pathogenic bacterial invasion in plantations has increased dramatically due to high environmental climate change and has seriously affected sweet orange fruit quality.
Xiuyao Yang, Mengjie Zhang, Dengxian Xi, Tuo Yin, Ling Zhu, Xiujia Yang, Xianyan Zhou, Hanyao Zhang, Xiaozhen Liu   +8 more
doaj   +2 more sources

Bradley, Robert Michael, 1947-2006 (MSS 138) [PDF]

, 2007
Finding aid only for Manuscripts Collection 138. Vietnam War letters written by Robert Michael Bradley to his parents Sue and Henry Bradley, Jr., of Bowling Green, Kentucky documenting his tour in Vietnam, July 6, 1968-July 5, 1969.
Folklife Archives, Manuscripts &
core   +1 more source