Results 171 to 180 of about 4,877,507 (345)

Agentes tutor e estilos de aprendizagem em ambientes adaptativos [PDF]

, 2008
O Processo de Bolonha que pretende mudar o paradigma educativo passando a estar centrado no aluno, é um dos maiores desafios que o ensino superior enfrenta actualmente.
Alves, Paulo
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Detection of KPC-producing Enterobacterales species in wastewater samples from the Gran Concepción Metropolitan area, Chile

Biological Research
Background Carbapenemase-mediated resistance to carbapenems is a significant public health concern due to its potential for widespread dissemination.
Franco Ilabaca-Carrasco, Carlos Peña-Raddatz, Claudia Torres-Bustos, Mauricio Hernández-Cea, Guillermo Nourdin-Galindo, Pablo Saldivia-Flandez, Cristian Vargas, Elard Koch, Helia Bello-Toledo, Gerardo González-Rocha, Andrés Opazo-Capurro   +10 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Soluciones Maxmin en Juegos de Negociación n-Personales [PDF]

, 2002
En este trabajo proponemos utilizar el criterio maxmin para obtener soluciones equilibradas en juegos de negociación de n agentes. Se analizan las relaciones existentes entre las soluciones obtenidas al utilizar un criterio consistente en la maximización
Monroy Berjillos, Luisa, Mármol Conde, Amparo María, Rubiales Caballero, Victoriana   +2 more
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Colonial Agents:

, 2009
This article traces relationships between German-speaking missionaries and politics in the English-speaking world of the eighteenth and nineteenth centuries. It particularly examines the relationship between Moravian missionaries and the colonial government in Victoria, Australia demonstrating how politics impinged upon missionary work.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Desarrollo de un Modelo del Agente Personal del Proyecto Paleta [PDF]

, 2001
59 p.El German Institute for Economic Research en conjunto con la Universidad de Talca están trabajando en PALETA, iniciativa que esta dentro del proyecto IRAIA, dirigido al desarrollo de una red de agentes que apoye los procesos automáticos de ...
Pereira Retamales, Javier (Prof. Guía), Rojas Henriquez, Claudio Andres   +1 more
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