Results 191 to 200 of about 388 (231)
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Naturally derived anti‐HIV agents
Phytotherapy Research, 2005AbstractThe urgent need for new anti‐HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti‐HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the ...
Asres, Kaleab +4 more
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Rationally Designed Multitarget Anti-HIV Agents
Current Medicinal Chemistry, 2013Multitarget-directed ligands (MTDLs), an emerging and appealing drug discovery strategy, utilizing a single chemical entity to inhibit multitargets, was confirmed to be effective in reducing the likelihood of drug resistance, diminishing problems of dosing complexity, drug-drug interactions and toxicities, as well as improving patient compliance.
P, Zhan, X, Liu
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New anti‐HIV agents and targets
Medicinal Research Reviews, 2002AbstractVirtually all the compounds that are currently used or are subject of advanced clinical trials for the treatment of HIV infections, belong to one of the following classes: (i) nucleoside reverse transcriptase inhibitors (NRTIs): i.e., zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, emtricitabine and nucleotide reverse ...
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Quinobene, a new potent anti-HIV agent
Biochemical and Biophysical Research Communications, 1992A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound.
E, Gruszecka-Kowalik +2 more
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DNA aptamers as potential anti-HIV agents
Trends in Biochemical Sciences, 2005Guanine (G)-rich DNA sequences can adopt stable G-quadruplex structures by G-tetrad hydrogen-bonding and hydrophobic stacking. Recently, it has been shown that a DNA sequence forms an aptamer (termed 93del) and adopts a novel dimeric quadruplex folding topology in K+ solution. This aptamer exhibits anti-HIV1 integrase activity in the nanomolar range in
Shan-Ho, Chou +2 more
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6-Aminoquinolones as New Potential Anti-HIV Agents
Journal of Medicinal Chemistry, 2000A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human ...
V. CECCHETTI +10 more
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Combinatorial Synthesis of anti‐HIV Agents
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Dharmarajan Sriram +2 more
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Natural Products as Anti- HIV Agents
Nigerian Quarterly Journal of Hospital Medicine, 2008Acquired immunodeficiency syndrome (AIDS) is a pandemic immunodegenerative disease caused by human immunodeficiency virus (HIV). The disease is ravaging, given the number of patients infected with the disease worldwide, the high mortality rate and attendant socio-economic casualties in affected countries, mostly in Africa.
Adesegun, S A, Ajayi, G O, Coker, H A
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Repurposing Phytochemicals as Anti-HIV Agents
Journal of Antivirals & Antiretrovirals, 2016Phytochemicals play crucial role in inhibiting key enzymes involved in HIV-1 replication. Repurposing of phytochemical based anti-HIV drug discovery through cross screening approaches and modern techniques is essential to provide better leads. Anti-HIV leads translated through phytochemicals could overcome current challenges of HIV therapy. Considering
Pratiksha Jadaun +2 more
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Nihon rinsho. Japanese journal of clinical medicine, 2012
Since the introduction of zidovudine into HIV clinical practice in 1985, the history of antiretroviral treatment has been started. Even in well controlled patients with HIV loads under the detection limit for many years, viral load rebound could occur followed by CD4 cell count decline, if the antiretroviral treatment is interrupted.
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Since the introduction of zidovudine into HIV clinical practice in 1985, the history of antiretroviral treatment has been started. Even in well controlled patients with HIV loads under the detection limit for many years, viral load rebound could occur followed by CD4 cell count decline, if the antiretroviral treatment is interrupted.
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