Results 121 to 130 of about 18,578 (279)

Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Type 2 Diabetes Mellitus

open access: yesHepatology Research, EarlyView.
This study evaluated the effects of tirzepatide in patients with Type 2 diabetes mellitus and metabolic dysfunction‐associated steatotic liver disease. After 48 weeks of treatment, patients showed significant improvements in liver steatosis and injury, surrogate markers of liver fibrosis, glycemic control, and body weight. ABSTRACT Aim This study aimed
Taeang Arai   +20 more
wiley   +1 more source

The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun   +5 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

open access: yesJournal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó   +4 more
wiley   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

open access: yesPlant Biotechnology Journal, EarlyView.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij   +7 more
wiley   +1 more source

Overexpression of miR399d impairs arbuscular mycorrhizal symbiosis in tomato

open access: yesPlant Biotechnology Journal, EarlyView.
Summary Arbuscular mycorrhizal symbiosis (AMS) is a pervasive mutualistic interaction that is prevalent among fungi and the majority of terrestrial plant species. AMS host plants possess an alternative phosphate (Pi) acquisition pathway via arbuscular mycorrhizal fungi (AMF) in addition to direct Pi uptake by the root epidermis.
Zhen Zeng   +10 more
wiley   +1 more source

Cold Agglutinin Disease in a Rhesus Macaque (<i>Macaca mulatta</i>). [PDF]

open access: yesComp Med, 2023
Kamperschroer C   +5 more
europepmc   +1 more source

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