Results 121 to 130 of about 1,588 (173)
Research progress of short stature and advanced bone age, early-onset osteoarthritis and osteochondritis dissecans (SSOAOD) caused by acan gene mutation. [PDF]
Front Endocrinol (Lausanne)Chen Y, Wu S, Gu W.
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Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content. [PDF]
PLoS Comput BiolEskelinen ASA +7 more
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Comparison of Concentration- and Homology-Dependent Effects of the Proinflammatory Cytokine Interleukin-1β (IL-1β) in a Bovine Chondrocyte Inflammation Model. [PDF]
CellsOssendorff R +10 more
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Some of the next articles are maybe not open access.
Matrix Biology, 1994
Large proteoglycans were purified by ion-exchange chromatography, gel filtration and CsCl gradient centrifugation from the compressed and tensional regions of adult bovine deep flexor tendon. Tryptic peptide maps of proteoglycan from the compressed region were very similar to maps of aggrecan from bovine articular cartilage, with evidence for the ...
K G, Vogel +3 more
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Large proteoglycans were purified by ion-exchange chromatography, gel filtration and CsCl gradient centrifugation from the compressed and tensional regions of adult bovine deep flexor tendon. Tryptic peptide maps of proteoglycan from the compressed region were very similar to maps of aggrecan from bovine articular cartilage, with evidence for the ...
K G, Vogel +3 more
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Aggrecan: Beyond cartilage and into the brain
The International Journal of Biochemistry & Cell Biology, 2012Aggrecan is well-studied in cartilage but its expression and function in the central nervous system has only recently begun to be appreciated. Aggrecan plays an important role in the organization of the neural extracellular space by binding and organizing hyaluronan to the cell surface through interactions with link protein and tenascins forming a ...
Morawski, M. +3 more
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Journal of Bone and Mineral Metabolism, 2000
terminal globular (G)1 domain and a C-terminal G3 domain that are joined by intervening nonglobular sequences of lengths characteristic for each core protein. In addition, the aggrecan core protein has a G2 domain. The G1, G2, and G3 domains each contain distinctive motifs, with each motif having its own folded structure (Fig. 1).
W, Luo +6 more
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terminal globular (G)1 domain and a C-terminal G3 domain that are joined by intervening nonglobular sequences of lengths characteristic for each core protein. In addition, the aggrecan core protein has a G2 domain. The G1, G2, and G3 domains each contain distinctive motifs, with each motif having its own folded structure (Fig. 1).
W, Luo +6 more
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Synthesis and characterization of an aggrecan mimic
Acta Biomaterialia, 2012Aggrecan (AGG) is a large, aggregating proteoglycan present throughout the body, but predominantly found in articular cartilage. The principle features of AGG, its hyaluronan (HA) binding domain and its abundance of covalently attached glycosaminoglycans (GAGs), make it an essential component of the functional ability of articular cartilage.
Jonathan C, Bernhard, Alyssa, Panitch
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Trends in Cell Biology, 1995
Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan.
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Aggrecan is a large and highly complex macromolecule, uniquely structured to fill space in the extracellular matrix (ECM) of cartilage. Lethal chondrodystrophies resulting from mutations in the structural gene for aggrecan demonstrate the serious consequences of the absence of aggrecan.
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Solution Structure and Dynamics of Cartilage Aggrecan
Biomacromolecules, 2006We studied the structure and dynamics of porcine laryngeal aggrecan in solution using a range of noninvasive techniques: dynamic light scattering (DLS), small-angle neutron scattering (SANS), video particle tracking (VPT) microrheology, and diffusing wave spectroscopy (DWS).
Papagiannopoulos, A. +3 more
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Mechanism of catabolism of aggrecan by articular cartilage
Archives of Biochemistry and Biophysics, 1992Characterization of aggrecan core protein peptides appearing in the medium of adult articular cartilage maintained in tissue culture showed that eight major peptides could be detected. The two largest peptides had the same N-terminal sequence as bovine aggrecan core protein and probably represent partly degraded aggrecan lost to the medium in the form ...
M Z, Ilic +3 more
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