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Analysis of Aggrecan Catabolism by Immunoblotting and Immunohistochemistry
2011Aggrecan is essential for the normal function of articular cartilage and intervertebral disc, where it provides the ability for the tissues to withstand compressive loading. This property depends on both the high charge density endowed by its numerous chondroitin sulfate and keratan sulfate chains and its ability to form large molecular aggregates via ...
Peter J, Roughley, John S, Mort
openaire +2 more sources
Aggrecan: Approaches to Study Biophysical and Biomechanical Properties
2014Aggrecan, the most abundant extracellular proteoglycan in cartilage (~35 % by dry weight), plays a key role in the biophysical and biomechanical properties of cartilage. Here, we review several approaches based on atomic force microscopy (AFM) to probe the physical, mechanical, and structural properties of aggrecan at the molecular level.
Hadi Tavakoli, Nia +2 more
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Molecular cloning and analysis of the protein modules of aggrecans
Experientia, 1993M L Tanzer
exaly
Structure and Interactions of Aggrecans: Statistical Thermodynamic Approach
Biophysical Journal, 2008Rikkert Nap, Igal Szleifer
exaly