Results 131 to 140 of about 1,588 (173)
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Aggrecan degradation in osteoarthritis and rheumatoid arthritis
Acta Orthopaedica Scandinavica, 1995Aggrecan turnover is critically important to maintain extracellular matrix homeostasis in articular cartilage. Cartilage aggrecan metabolism has been studied in chondrocyte cell cultures, cartilage explant cultures, and in whole animal models. In many of these studies, matrix metalloproteinases (MMPs) are proposed to degrade cartilage aggrecan.
M W, Lark, E K, Bayne, L S, Lohmander
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Journal of Rheology, 2002
Aggrecan is the self-assembling proteoglycan complex whose physiological function is to provide a hydrated gel in cartilage that stabilizes the spatial distribution of the collagen fibers, and absorbs and resists compressive loads. The linear and nonlinear viscoelastic behavior of aggrecan solutions was studied as a function of aggrecan concentration ...
Nispa Meechai +4 more
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Aggrecan is the self-assembling proteoglycan complex whose physiological function is to provide a hydrated gel in cartilage that stabilizes the spatial distribution of the collagen fibers, and absorbs and resists compressive loads. The linear and nonlinear viscoelastic behavior of aggrecan solutions was studied as a function of aggrecan concentration ...
Nispa Meechai +4 more
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Complete sequencing and characterization of equine aggrecan
Veterinary and Comparative Orthopaedics and Traumatology, 2015SummaryObjectives: To fully sequence and characterize equine aggrecan and confirm conservation of major aggrecanase, calpain and matrix metalloproteinase (MMP) cleavage sites.Methods: Reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends were used to generate clones that encompassed the complete equine aggrecan sequence ...
E H G, Caporali +2 more
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Perspectives on developmental neurobiology, 1997
During development, the extracellular matrix (ECM) is a complex dynamic structure whose components and organization help to establish the requisite position and state of differentiation. Until recently, the large chondroitin sulfate proteoglycan, aggrecan, has been localized predominantly to skeletal tissue and considered a hallmark of cartilage ...
N B, Schwartz +4 more
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During development, the extracellular matrix (ECM) is a complex dynamic structure whose components and organization help to establish the requisite position and state of differentiation. Until recently, the large chondroitin sulfate proteoglycan, aggrecan, has been localized predominantly to skeletal tissue and considered a hallmark of cartilage ...
N B, Schwartz +4 more
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Compressive nanomechanics of opposing aggrecan macromolecules
Journal of Biomechanics, 2006In this study, we have measured the nanoscale compressive interactions between opposing aggrecan macromolecules in near-physiological conditions, in order to elucidate the molecular origins of tissue-level cartilage biomechanical behavior. Aggrecan molecules from fetal bovine epiphyseal cartilage were chemically end-grafted to planar substrates ...
Delphine, Dean +3 more
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Aggrecan, aging and assembly in articular cartilage
Cellular and Molecular Life Sciences, 2005The primary function of articular cartilage to act as a self-renewing, low frictional material that can distribute load efficiently at joints is critically dependent upon the composition and organisation of the extracellular matrix. Aggrecan is a major component of the extracellular matrix, forming high molecular weight aggregates necessary for the ...
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2002
Hyaluronan (HA) is a high molecular weight (105-107Da) unbranched glycosaminoglycan, composed of repeating disaccharides of D-N-Acetylglucosamine and D-Glucuronic acid. It is a widely distributed component of the extracellular matrix of vertebrate tissues [1].
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Hyaluronan (HA) is a high molecular weight (105-107Da) unbranched glycosaminoglycan, composed of repeating disaccharides of D-N-Acetylglucosamine and D-Glucuronic acid. It is a widely distributed component of the extracellular matrix of vertebrate tissues [1].
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Changes in aggrecan populations in experimental osteoarthritis
Osteoarthritis and Cartilage, 1994Adult articular cartilage contains at least two distinct populations of aggrecan: one is larger and richer in chondroitin sulfate (CS), while the other is smaller with less CS. The smaller form is thought to be derived from the larger. The amount of CS in cartilage decreases with maturation and aging, mainly because of a decrease in the proportion of ...
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Agents and Actions, 1993
Bovine nasal septum aggrecan and selected proteinase-digested products of aggrecan were evaluated in an inhibition ELISA using the anti-keratan sulfate (KS) monoclonal antibody 5-D-4 (5D4). Undegraded aggrecan was recognized with an IC50 of 0.27 microgram/ml.
C A, Saphos +3 more
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Bovine nasal septum aggrecan and selected proteinase-digested products of aggrecan were evaluated in an inhibition ELISA using the anti-keratan sulfate (KS) monoclonal antibody 5-D-4 (5D4). Undegraded aggrecan was recognized with an IC50 of 0.27 microgram/ml.
C A, Saphos +3 more
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Biorheology: The Official Journal of the International Society of Biorheology, 2004
We determined elasticity (G′) and viscosity (G″) of various aggrecan–hyaluronan solutions using a controlled‐stress rheometer with high (10 Hz) to low (0.1 Hz) frequencies. Aggrecan solution (50 mg/ml) alone showed little elasticity at any frequency, but the addition of 3300 kDa hyaluronan at 0.001–0.1 mg/ml markedly increased the elasticity, but not ...
M, Nishimura +7 more
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We determined elasticity (G′) and viscosity (G″) of various aggrecan–hyaluronan solutions using a controlled‐stress rheometer with high (10 Hz) to low (0.1 Hz) frequencies. Aggrecan solution (50 mg/ml) alone showed little elasticity at any frequency, but the addition of 3300 kDa hyaluronan at 0.001–0.1 mg/ml markedly increased the elasticity, but not ...
M, Nishimura +7 more
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