Results 71 to 80 of about 14,008 (211)

Prognostic value of aggregate index of systemic inflammation in acute ischemic stroke mortality

Turkish Journal of Clinics and Laboratory
Aim: Systemic inflammation plays a key role in the pathophysiology of acute ischemic stroke (AIS), influencing disease severity and outcomes. The Aggregate Index of Systemic Inflammation (AISI) is a novel inflammatory biomarker that integrates multiple hematological parameters.
Neslihan Ergün Süzer, Mehmet Ozel
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Inflammatory indices AISI and SIRI in atherosclerosis risk stratification: validation across community and intensive care populations

Annals of Medicine
Background Systemic inflammation plays a key role in atherosclerosis development. This study evaluated the predictive performance of two composite inflammatory indices—the Aggregate Index of Systemic Inflammation (AISI) and the Systemic Inflammation ...
Jing Tang, Ting-xin Li, Ling Deng, Xin-cheng Huang, Pei-yuan He, Han Zhao   +5 more
doaj   +1 more source

AGGREGATE INDEX OF SYSTEMIC INFLAMMATION (AISI) IN SURVIVOR AND NON-SURVIVOR SEPSIS PATIENTS

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
Sepsis is a serious condition characterized by organ dysfunction resulting from an inappropriate immune response to infection. It is one of the primary causes of death and illness among critically ill patients, and its occurrence has risen over the past century.
Siti Fajrini Amir, Asvin Nurulita, Uleng Bahrun   +2 more
openaire   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Computed tomography-based association of hematological parameters and systemic inflammation markers with COVID-19 severity in hospitalized patients

Инфекция и иммунитет
Laboratory data are important for confirming diagnosis, assessing COVID-19 progression, and determining treatment measures. The aim of this study was to evaluate the associations of hematological, coagulation parameters, and systemic inflammatory markers
Marina E. Dyakova, A. V. Makarova, O. L. Rubtsova, D. S. Esmedlyaeva, P. K. Yablonskiy   +4 more
doaj   +1 more source

The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients

Molecules, 2020
Background. The rapid onset of a systemic pro-inflammatory state followed by acute respiratory distress syndrome is the leading cause of mortality in patients with COVID-19.
Alessandro G. Fois, Panagiotis Paliogiannis, Valentina Scano, Stefania Cau, Sergio Babudieri, Roberto Perra, Giulia Ruzzittu, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Luigi B. Arru, Alessandro Fancellu, Michele Mondoni, Arduino A. Mangoni, Angelo Zinellu   +14 more
doaj   +1 more source

Prognostic value of the aggregate index of systemic inflammation in palliative care patients

Scientific Reports
Abstract Accurate prognostication remains essential for appropriate care planning in palliative care settings. The Aggregate Index of Systemic Inflammation (AISI) represents a comprehensive integration of four inflammatory cell populations, but its comparative prognostic value in palliative care has not been ...
Evren Ekingen, Mete Ucdal
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source