Results 81 to 90 of about 14,097 (232)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

, 2022
Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB).
Olasińska-Wiśniewska, Anna, Urbanowicz, Tomasz, Michalak, Michał, Jemielity, Marek, Anna Olasińska-Wiśniewska, Aleksandra Gąsecka, Bartłomiej Perek, Marek Jemielity, Gąsecka, Aleksandra, Witkowska, Anna, Piotr Buczkowski, Buczkowski, Piotr, Rodzki, Michał, Tomasz Urbanowicz, Michał Michalak, Michał Rodzki, Anna Witkowska, Perek, Bartłomiej   +17 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Is it possible to use complete blood collection based systemic inflammatory indices as potential biomarkers for chronic spontaneous urticaria

Frontiers in Immunology
Chronic spontaneous urticaria (CSU) is mediated not only by mast cells but also by eosinophils and basophils. We evaluated whether complete blood collection based systemic inflammatory indices- including the systemic immune-inflammation index (SII ...
Bingyu Li, Bingyu Li, Lu Peng, Lu Peng, Runqing Li, Mai Shi, Mai Shi, Yingyi Li, Yingyi Li, Chinghsuan Sun, Chinghsuan Sun, Zhuying Zhang, Zhuying Zhang, Jingwen Xue, Jingwen Xue, Yi Zhao, Yi Zhao   +16 more
doaj   +1 more source

Relationship Between Preoperative Inflammation Ratios Derived From Preoperative Blood Cell Count and Postoperative Pulmonary Complications in Patients Undergoing Lobectomy: A Single-Center Observational Study

, 2023
International audienceAbstractObjective: Evaluation of the association of inflammatory cell ratios, especially neutrophil-to-lymphocyte ratio (NLR), based on preoperative complete blood counts, with postoperative complications in lobectomy surgery.Design:
Vallée, Alexandre, Fischler, Marc, Salze, Benjamin, Fessler, Julien, de Fréminville, Amaury, Pricopi, Ciprian, Trillat, Bernard, Saad, Mary, Vasse, Marc, Pascreau, Tiffany, Sage, Édouard, Guen, Morgan Le   +11 more
core   +1 more source

Prognostic value of aggregate index of systemic inflammation in acute ischemic stroke mortality

Turkish Journal of Clinics and Laboratory
Aim: Systemic inflammation plays a key role in the pathophysiology of acute ischemic stroke (AIS), influencing disease severity and outcomes. The Aggregate Index of Systemic Inflammation (AISI) is a novel inflammatory biomarker that integrates multiple hematological parameters.
Neslihan Ergün Süzer, Mehmet Ozel
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

AGGREGATE INDEX OF SYSTEMIC INFLAMMATION (AISI) IN SURVIVOR AND NON-SURVIVOR SEPSIS PATIENTS

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
Sepsis is a serious condition characterized by organ dysfunction resulting from an inappropriate immune response to infection. It is one of the primary causes of death and illness among critically ill patients, and its occurrence has risen over the past century.
Siti Fajrini Amir, Asvin Nurulita, Uleng Bahrun   +2 more
openaire   +1 more source