Results 81 to 90 of about 174,204,952 (254)

Association between chronic inflammation status and serum testosterone and free testosterone in adult males

The Aging Male
Background Chronic inflammation may contribute to biochemical hypogonadism, but evidence regarding composite inflammatory indicators is limited. This study examined the associations of the systemic inflammation response index (SIRI) and aggregate index ...
Si-zheng Zhang, Yu-hang Meng, Shuai-dang Qi, Jie Wu, Liang Su, Yong-zheng Jiao   +5 more
doaj   +1 more source

Prognostic Value of Systemic Immune-inflammation Index in Patients with Pediatric Blunt Abdominal Trauma [PDF]

Objective: Trauma is a leading cause of morbidity and mortality in children. One in every four patients with trauma has abdominal trauma. Abdominal trauma is the third leading cause of death associated with trauma.
Adem Çakır, Semih Korkut, Ertuğrul Altuğ, İbrahim Altundağ, Kemal Şener, Ramazan Güven   +5 more
core   +1 more source

Systemic inflammation response index (SIRI) as predictor of anastomotic leakage after total gastrectomy for gastric cancer

, 2022
Esophago-jejunostomy leakage (EJL) it the most dreaded septic complication after total gastrectomy for gastric cancer. Early detection and treatment of this complication may improve outcomes.
Carlei F., Schiavi D., Giuliani A., Pessia B., Schietroma M., Romano L., Mattei A., Fiasca F.   +7 more
core   +1 more source

Association between sarcopenic obesity and cardiovascular diseases: the role of systemic inflammation indices

Frontiers in Medicine
BackgroundResearch on the relationship between sarcopenic obesity (SO) and multiple cardiovascular diseases is limited, and the regulatory roles of the Aggregate Index of Systemic Inflammation (AISI) and Systemic Inflammation Response Index (SIRI) remain
Yuhong Luo, Yuhong Luo, Chen Xin, Chen Xin, Yuhua Liu, Yuhua Liu, Yan Xu, Yan Xu, Guixin Liu, Guixin Liu, Binru Han, Binru Han   +11 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Association between vitamin D and inflammatory markers in the Chinese healthy adult population: a cross-sectional study

Food & Nutrition Research
Background/Objectives: Vitamin D (VitD) plays an essential role in immune regulation, and growing evidence associates low VitD status with elevated systemic inflammation.
Ye Hu, Hongxiao Li, Yi Chen, Yubei Yang, Yubo Xing, Jie Xiang, Lina Shao   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The systemic inflammation index on admission is independently associated with length of stay in hospitalized COVID-19 patients

, 2021
BACKGROUND: The early detection of factors predicting hospital length of stay (LOS) in patients affected by severe acute respiratory syndrome in Coronavirus 2 (SARS-CoV-2) disease (COVID-19) might facilitate therapeutic decisions and patient flow ...
Fois A. G., Zinellu A., Vaira L. A., Scano V., Pirina P., Mangoni A. A., Babudieri S., Carru C., de Riu G., Masotto E.   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source