Results 51 to 60 of about 345,702 (307)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Un modelo de optimización para planificar la producción de una compañía siderúrgica

Ingenieria Industrial, 2009
En este trabajo se resuelve un problema de planificación agregada de la producción de Compañía Siderúrgica Huachipato S.A., a través de un modelo de programación lineal. La planificación agregada de la producción es a mediano plazo, en donde se considera
Felipe Alvarez Clifford, Hernaldo Reinoso   +1 more
doaj  

System of Parametric Modelling and Assessing the Production Staff Utilisation as a Basis for Aggregate Production Planning

Applied Sciences, 2021
The requirement to achieve effective solutions in the shortest possible time in the manufacturing environment is essential, and it can be solved only by effective production planning methods.
Martin Krajčovič, Beáta Furmannová, Patrik Grznár, Radovan Furmann, Dariusz Plinta, Radovan Svitek, Ivan Antoniuk   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Production Decision Support System for Multi-product with Multiple Different Size Processors

Chemical Engineering Transactions, 2018
Aggregate planning is an operational activity with the objective of providing upfront information on quantity of material to be procured and resources to be secured. At a point of time, it might also influence both demand and supply.
Lee Pheng Chee, Sharifah Rafidah Wan Alwi, Jeng Shiun Lim   +2 more
doaj   +1 more source

Pathophysiology, histopathology and therapeutic of SARS-CoV-2 [PDF]

, 2020
The rapid transmission of SARS-CoV-2 through the world has induced the scientist to understand the histopathology of the virus and then to find an effective drug.
Al-Gheethi, Adel, Al-Shorgani, Najeeb, Hezam, Kamal, Noman, Efaq, Othman, Norzila, Radin Mohamed, Radin Maya Saphira, Talip, Balkis   +6 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Aggregate Production Planning for Cost Optimization: A Case Study of Van’z Collection, a Small-Scale Garment Manufacturer

Society
This study aims to evaluate the aggregate production planning system and explore alternative aggregate strategies to improve cost efficiency in the production planning process.
Zahra Nur Afifah, Ayi Tejaningrum
doaj   +1 more source

Modeling an aggregate production planning

, 2022
This paper aims to present and discuss the benefits that small- and medium-sized companies can get when using mathematical programming to help in the decision-making process regarding aggregate production planning. The aggregate plan is concerned with determining the quantity of a good or a family of goods to be produced and also scheduling its ...
Zanella, Fernando, Vaz, Clara B.
openaire   +2 more sources