Results 71 to 80 of about 20,398 (300)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Hierarchical production planning for consumer goods
, 1990 In this paper the mathematical logic behind a hierarchical planning procedure is discussed. The planning procedure is used to derive production volumes of consumer products.
Kok, de, A.G., Kok, de, A.G.; id_orcid
core +1 more source
Desining a Multi-Objective Mathematical Model of Cumulative Production Planning in Reverse Supply Chain With Production Quality Function Under Uncertainty and Using MPSOGA Tran-Innovation Algorithm (High-Tech Industry Case Study) [PDF]
مدیریت مهندسی و رایانش نرم, 2023 In the present paper, the cogeneration program in the form of an inverse supply chain using multi-objective mathematical modeling in conditions of uncertainty is considered.
Saeid Rezaie Moghadam, Aslan Doosti
doaj
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Production planning of biopharmaceutical manufacture.
, 2006 Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation ...
Lakhdar, K.
core
Investigating the Relationship between Planning Reliability and Project Performance
, 2008 Variability is a well-known problem in construction projects, which leads to the general deterioration of project performance. During the last decade, the Last Planner System (LPS"), a production planning and control system based on lean production ...
Alarcon, LF +5 more
core +1 more source
International Journal of Production Management and Engineering, 2017 In this paper a multi-period multi-product multi-objective aggregate production planning (APP) model is proposed for an uncertain multi-echelon supply chain considering financial risk, customer satisfaction, and human resource training. Three conflictive
Kaveh Khalili-Damghani +2 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source