Results 81 to 90 of about 8,534,336 (300)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Aggregate Production Planning Techniques and Comparison [PDF]

, 1977
Aggregate production planning models are of the greatest importance to operations management, since these plans enable management to utilize the major resources at its command.
Mazaheri, Fariborz
core  

Aggregate procurement, production, and shipment planning decision problem for a three-echelon supply chain using swarm-based heuristics

, 2011
Supplier selection is deemed as a crucial strategic decision-making activity in building a competitive edge. Firms prefer to operate with a few trusted suppliers, selected from a bigger pool of vendors. The chosen suppliers are the ones whose commitments
Mahanty, B, Pal, A., Tiwari, M.K., Chan, F.T.S., Pal, A, Chan, FTS, Tiwari, MK, Mahanty, B.   +7 more
core   +1 more source

An Integrated ANN-Aggregate Planning-RCCP Framework for Make-to-Stock Bag Production: A Case Study of Keyna Products

Jurnal Ilmiah Teknik Industri
Company XYZ applies a make-to-stock (MTS) system for bag production, where inaccurate demand estimation can cause overstock, stockouts, and infeasible shop floor plans. This study proposes an integrated planning framework for the Keyna product family by
Ahmad Ilham, Iveline Anne Marie, Annisa Dewi Akbari   +2 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Endogenous Aggregate Elasticity of Substitution [PDF]

In the literature studying aggregate economies the aggregate elasticity of substitution (AES) between capital and labor is often treated as a constant or “deep” parameter. This view contrasts with the conjecture put forward by Arrow et al.
Chris Papageorgiou, Kaz Miyagiwa
core  

Hierarchical production planning for consumer goods

, 1990
In this paper the mathematical logic behind a hierarchical planning procedure is discussed. The planning procedure is used to derive production volumes of consumer products.
Kok, de, A.G., Kok, de, A.G.; id_orcid
core   +1 more source

Stochastic multi-period multi-product multi-objective Aggregate Production Planning model in multi-echelon supply chain

International Journal of Production Management and Engineering, 2017
In this paper a multi-period multi-product multi-objective aggregate production planning (APP) model is proposed for an uncertain multi-echelon supply chain considering financial risk, customer satisfaction, and human resource training. Three conflictive
Kaveh Khalili-Damghani, Ayda Shahrokh, Alireza Pakgohar   +2 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Order logistics for discrete and continual production processes in industry 4.0 conditions

Metalurgija, 2021
The basic goal of the article is to define changes in production logistics and its essential part of order logistics at the transformation of the production system from an automated management system with the participation of first level logistics ...
D. Malindžak, P. Kačmary, A. Gazda, E. Mihalikova   +3 more
doaj