Results 71 to 80 of about 5,001,808 (350)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Long-term impact of no-till conservation agriculture and N-fertilizer on soil aggregate stability, infiltration and distribution of C in different size fractions

Soil & Tillage Research, 2019
Soil degradation associated with the loss of soil organic carbon (SOC) has been a major concern in sub-Saharan Africa because of the subsequent yield reduction.
N. Sithole, Lembe S. Magwaza, G. Thibaud
semanticscholar   +1 more source

Effect of Crop Residue Decomposition on Soil Aggregate Stability

Agriculture, 2020
The decomposition of fresh crop residues added to soil for agricultural purposes is complex. This is due to different factors that influence the decomposition process. In field conditions, the incorporation of crop residues into soil does not always have
Gheorghe Stegarescu, Jordi Escuer-Gatius, K. Soosaar, K. Kauer, T. Tõnutare, A. Astover, E. Reintam   +6 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Responses of soil aggregate characteristics to grazing intensity differ between topsoil and subsoil in a typical steppe

Frontiers in Environmental Science
Soil aggregates are vital to soil structure, influencing grassland ecosystem health and sustainability. As a dominant land use in grasslands, grazing acts as a key driver of ecosystem structure and function, yet the responses of aggregate size ...
Hao Li, Zeyu Yang, Xiao Guo, Hangyu Li, Xing Li, Yantao Wu, Ying Han, Zhiyong Li, Jinghui Zhang, Bailing Miao, Cunzhu Liang   +10 more
doaj   +1 more source

Kosmotropes and chaotropes: modelling preferential exclusion, binding and aggregate stability [PDF]

, 2004
Kosmotropic cosolvents added to an aqueous solution promote the aggregation of hydrophobic solute particles, while chaotropic cosolvents act to destabilise such aggregates. We discuss the mechanism for these phenomena within an adapted version of the two-
Moelbert, Susanne, Normand, B., Rios, Paolo De Los   +2 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

RECIPROCAL RELATIONSHIPS BETWEEN AGGREGATE STABILITY AND ORGANIC CARBON CHARACTERISTICS IN A FORESTED ECOSYSTEM OF NORTHERN NIGERIA

Tropical and Subtropical Agroecosystems, 2012
Soil organic matter associated with different size aggregates differ in structure and function; therefore, play different roles in soil organic carbon (SOC) turnover.
Halima Mohammed Lawal
doaj