Results 101 to 110 of about 444,396 (337)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection

Smart Molecules
A binder‐free Ru@NiMoS electrode was engineered by in situ growth of two‐dimensional NiMoS nanosheets on nickel foam. This process effectively promoted the electrostatic‐driven aggregation of Ru(bpy)32+, harnessing the synergistic effect to enhance ...
Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang   +9 more
doaj   +1 more source

Strain sensing based on radiative emission-absorption mechanism using dye-doped polymer optical fiber [PDF]

, 2017
A stress sensor based on a dye-doped polymeric optical fiber is able to detect stress by simple comparison of two luminescence peaks from a pair of energy transfer organic dyes. Coumarin 540A (donor) and Rhodamine 6G (acceptor) were doped in the core and
R. Furukawa, S. Kamimura
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Photocatalytic therapy via photoinduced redox imbalance in biological system

Nature Communications
Redox balance is essential for sustaining normal physiological metabolic activities of life. In this study, we present a photocatalytic system to perturb the balance of NADH/NAD+ in oxygen-free conditions, achieving photocatalytic therapy to cure ...
Kun Zhou, Lili Du, Rui Ding, Letian Xu, Shuai Shi, Siyuan Wang, Zaiyu Wang, Guoqing Zhang, Gang He, Zheng Zhao, Ben Zhong Tang   +10 more
doaj   +1 more source

Organic luminescent materials: The concentration on aggregates from aggregation‐induced emission

Aggregate, 2020
The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications. To adjust the luminescent properties for aggregates, a deep understanding of the corresponding internal mechanism is needed. In this
Jie Yang, Manman Fang, Zhen Li
doaj   +1 more source

Ionized Nitrogen Mono-hydride Bands are Identified in the Pre-solar and Carbonado Diamond Spectra

, 2011
None of the well established Nitrogen related IR absorption bands, common in synthetic and terrestrial diamonds, have been identified in the pre-solar diamond spectra.
Adams, Amari, Anders, Andersen, Braatz, Cheung, Colangeli, Collins, Crawford, Davis, Demeny, Field, Garai, Hill, Hily-Blant, Huebner, Jones, Jones, Kagi, Koike, Lawson, Lawson, Lewis, Lewis, McNamara, Meier, Meyer, Mitchell, Mutschke, Mutschke, Persson, Samoilovitch, Schmitt, Swings   +33 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

STM-induced surface aggregates on metals and oxidized silicon

, 2011
We have observed an aggregation of carbon or carbon derivatives on platinum and natively oxidized silicon surfaces during STM measurements in ultra-high vacuum on solvent-cleaned samples previously structured by e-beam lithography.
Baba, Beebe, Berner, Dominik Stöffler, Ehrichs, Hilbert v. Löhneysen, Kiguchi, Koops, Mamin, Miura, Miura, Morita, Mühl, Rauscher, Regina Hoffmann, Young   +15 more
core   +1 more source