Results 41 to 50 of about 136,936 (263)

Hetero-Aggregation-Induced Tunable Emission in Multicomponent Crystals

, 2023
Crystal engineering is a green and convenient approach to designing desirable materials through rational manipulation of intermolecular interactions. We have reported the lesser reported sulfonate–pyridinium intermolecular interaction for the design and ...
Abhishek K. Gupta (9654537), Aadil A. Ahangar (6939683), Abhishek K. Gupta, Aijaz A. Dar (1518667), Arshid A. Ganie, Abhimanew Dhir (2368180), Aadil A. Ahangar, Arshid A. Ganie (6469805), Abhimanew Dhir, Aijaz A. Dar   +9 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Applications of AIEgens in Super-Resolution Imaging, Fluorescence Lifetime Imaging, and Fluorescence Anisotropy Imaging

, 2018
Aggregation-induced emission (AIE) luminogens (AIEgens) are emerging as a new class of luminescent materials for bioimaging. They are usually with excellent optical properties, appreciable biocompatibility and thus have been used extensively for cell ...
Engui Zhao, Sijie Chen, Zhao, E, Chen, S
core   +1 more source

Photo‐induced Bacillus subtilis‐spore transformation for bowel disease therapy and therapeutic outcome visualization

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Efficient strategies for transforming Bacillus subtilis vegetative cells into spores (BtS transformation) are still limited, although they show promise for the treatment of inflammatory bowel disease (IBD).
Lin Kong, Wei He, Junyi Gong, Zijie Qiu, Zheng Zhao, Ben Zhong Tang   +5 more
doaj   +1 more source

Regulating the proximity effect of heterocycle-containing AIEgens

Nature Communications, 2023
Proximity effect, which refers to the low-lying (n,π*) and (π,π*) states with close energy levels, usually plays a negative role in the luminescent behaviors of heterocyclic luminogens.
Jianyu Zhang, Yujie Tu, Hanchen Shen, Jacky W. Y. Lam, Jianwei Sun, Haoke Zhang, Ben Zhong Tang   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reverse Thinking of Aggregation-Induced Emission Principle: Amplifying Molecular Motions to Boost Photothermal Efficiency of Nanofibers

, 2020
Development of efficient photothermal nanofibers is of vital importance, but remaining a big challenge. Herein, with reverse thinking of aggregation-induced emission (AIE) principle, we demonstrate an ingenious and universal protocol for amplifying ...
Haoxuan, Li, Ben Zhong, Tang, Dong, Wang, Zhijun, Zhang, Nan, Song, Haifei, Wen   +5 more
core   +1 more source

Tailored Broad-Spectrum Emission in Hybrid Aggregation Induced Emission (AIE)-MOFs: Boosting White Light Efficiency in Electrospun Janus Microfibers

, 2023
Advances in energy-efficient lighting and display technologies demand innovative materials with tailored broad-spectrum emission properties. Hybrid aggregation-induced emission metal-organic frameworks (AIE-MOFs) offer a promising avenue, combining ...
Samraj, Mollick, Vishal, Kachwal, Jin-Chong, Tan   +2 more
core   +1 more source

Molecular Engineering‐Boosted High‐Performance AIE Sonosensitizer for Cancer Sonodynamic‐Augmented Immunotherapy

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Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of
Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu   +10 more
doaj   +1 more source