Results 51 to 60 of about 444,396 (337)

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, 2022
Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elements: photosensitizers (PSs), light and oxygen.
Zijuan Meng, Huiying Xue, Tingting Wang, Biao Chen, Xiyuan Dong, Lili Yang, Jun Dai, Xiaoding Lou, Fan Xia   +8 more
semanticscholar   +1 more source

Synthesis and Characterization of Diketopyrrolopyrrole-Based Aggregation-Induced Emission Nanoparticles for Bioimaging

Molecules, 2022
Conventional fluorescent dyes have the property of decreasing fluorescence due to aggregation-caused quenching effects at high concentrations, whereas aggregation-induced emission dyes have the property of increasing fluorescence as they aggregate with ...
Geonho Lee, Jongwook Park, Seong Hyun Jang, Sang Yoon Lee, Jihyun Seong, Jae Woong Jung, Kyobum Kim, Tae Gyu Hwang, Jun Choi   +8 more
doaj   +1 more source

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins [PDF]

, 2018
Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways.
Baglivo, I, Coletta, M, D'Abrosca, G, De Stefano, M, Fattorusso, R., Gianni, S, Isernia, C, Majewska, R, Malgieri, G, Milardi, D, Palmieri, M, Pedone, Em, Pedone, Pv, Pirone, L, Russo, L, Sciacca, Mfm, Sivo, V, Tatè, R, Toto, A   +18 more
core   +2 more sources

Enzymatically catalyzed molecular aggregation

Nature Communications
The dynamic modulation of the aggregation process of small molecules represents an important research objective for scientists. However, the complex and dynamic nature of internal environments in vivo impedes controllable aggregation processes of single ...
Wen-Jin Wang, Rongyuan Zhang, Liping Zhang, Liang Hao, Xu-Min Cai, Qian Wu, Zijie Qiu, Ruijuan Han, Jing Feng, Shaojuan Wang, Parvej Alam, Guoqing Zhang, Zheng Zhao, Ben Zhong Tang   +13 more
doaj   +1 more source

Correlative Microscopy of Morphology and Luminescence of Cu porphyrin aggregates

, 2017
Transfer of energy and information through molecule aggregates requires as one important building block anisotropic, cable-like structures. Knowledge on the spatial correlation of luminescence and morphology represents a prerequisite in the understanding
Bahrami, M., Barke, I., Becker, J., Behle, H., Elemans, J. A. A. W., Hartmann, H., Kraft, S., Speller, S., Vogler, B., Wardelmann, K.   +9 more
core   +2 more sources

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease [PDF]

, 2015
Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown.
Andrey Y. Abramov, Blerida Banushi, Christopher M. Dobson, Daniel Little, David Klenerman, Dias V, Emma Deas, Marthe H.R. Ludtmann, Mathew H. Horrocks, Michael J. Devine, Nicholas W. Wood, Nunilo Cremades, Paul Gissen, Plamena R. Angelova, Serene Chen, Sonia Gandhi, Zhi Yao   +16 more
core   +5 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Aggregation‐induced emission materials for nonlinear optics

Aggregate, 2021
Aggregation‐induced emission (AIE) is a vital photophysical phenomenon that the luminogens in the concentrated or aggregated cases will engender the dramatically boosted emission in comparison with the dispersive states. Given this extraordinary emitting
Xiao Han, Fei Ge, Jialiang Xu, Xian‐He Bu   +3 more
doaj   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source