Results 51 to 60 of about 4,549,568 (211)

Regulating the proximity effect of heterocycle-containing AIEgens

Nature Communications, 2023
Proximity effect, which refers to the low-lying (n,π*) and (π,π*) states with close energy levels, usually plays a negative role in the luminescent behaviors of heterocyclic luminogens.
Jianyu Zhang, Yujie Tu, Hanchen Shen, Jacky W. Y. Lam, Jianwei Sun, Haoke Zhang, Ben Zhong Tang   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Applications of AIEgens in Super-Resolution Imaging, Fluorescence Lifetime Imaging, and Fluorescence Anisotropy Imaging

, 2018
Aggregation-induced emission (AIE) luminogens (AIEgens) are emerging as a new class of luminescent materials for bioimaging. They are usually with excellent optical properties, appreciable biocompatibility and thus have been used extensively for cell ...
Engui Zhao, Sijie Chen, Zhao, E, Chen, S
core   +1 more source

Hetero-Aggregation-Induced Tunable Emission in Multicomponent Crystals

, 2023
Crystal engineering is a green and convenient approach to designing desirable materials through rational manipulation of intermolecular interactions. We have reported the lesser reported sulfonate–pyridinium intermolecular interaction for the design and ...
Abhishek K. Gupta (9654537), Aadil A. Ahangar (6939683), Abhishek K. Gupta, Aijaz A. Dar (1518667), Arshid A. Ganie, Abhimanew Dhir (2368180), Aadil A. Ahangar, Arshid A. Ganie (6469805), Abhimanew Dhir, Aijaz A. Dar   +9 more
core   +1 more source

Molecular Engineering‐Boosted High‐Performance AIE Sonosensitizer for Cancer Sonodynamic‐Augmented Immunotherapy

Aggregate
Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of
Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu   +10 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Room Temperature Phosphorescent Nanofiber Membranes by Bio‐Fermentation

Advanced Science
Stimuli‐responsive materials exhibiting exceptional room temperature phosphorescence (RTP) hold promise for emerging technologies. However, constructing such systems in a sustainable, scalable, and processable manner remains challenging.
Xiaolin Nie, Junyi Gong, Zeyang Ding, Bo Wu, Wen‐Jin Wang, Feng Gao, Guoqing Zhang, Parvej Alam, Yu Xiong, Zheng Zhao, Zijie Qiu, Ben Zhong Tang   +11 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Aggregation‐induced emission systems involving supramolecular assembly

Aggregate, 2020
Aggregation‐induced emission (AIE), as an exciting photophysical phenomenon, has been regarded as one frontier research topic within both ranges of molecular luminescence and materials science over the last two decades.
Xin‐Yue Lou, Ying‐Wei Yang
doaj   +1 more source