Results 71 to 80 of about 4,549,568 (211)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection

Smart Molecules
A binder‐free Ru@NiMoS electrode was engineered by in situ growth of two‐dimensional NiMoS nanosheets on nickel foam. This process effectively promoted the electrostatic‐driven aggregation of Ru(bpy)32+, harnessing the synergistic effect to enhance ...
Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang   +9 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aggregation-Induced Emission of a Two-Dimensional Covalent Organic Framework for Molecular Recognition in Quantitative Metrics

, 2023
Fluorescent porous materials have been intensively examined owing to their versatile applications in molecular recognition and chemical sensing. Although many studies on luminescent two-dimensional (2D) covalent organic frameworks (COFs) for chemical ...
Yongwu Peng, Chenglong Guo (11880311), Yongwu Peng (1415512), Guodong Xu, Dejun Zhou (2352136), Peng Jin (216301), Jiahao Li (2184729), Jiahao Li, Dejun Zhou, Chenglong Guo, Guodong Xu (479781), Peng Jin   +11 more
core   +1 more source

Photocatalytic therapy via photoinduced redox imbalance in biological system

Nature Communications
Redox balance is essential for sustaining normal physiological metabolic activities of life. In this study, we present a photocatalytic system to perturb the balance of NADH/NAD+ in oxygen-free conditions, achieving photocatalytic therapy to cure ...
Kun Zhou, Lili Du, Rui Ding, Letian Xu, Shuai Shi, Siyuan Wang, Zaiyu Wang, Guoqing Zhang, Gang He, Zheng Zhao, Ben Zhong Tang   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Aggregation-Induced Emission Materials with Narrowed Emission Band by Light-Harvesting Strategy: Fluorescence and Chemiluminescence Imaging

, 2019
Aggregation-induced emission luminogens (AIEgens) have attracted increasing attention in recent years on account of their attribute of overcoming the aggregation-caused quenching (ACQ) phenomenon of conventional organic fluorophores.
Jian-Xin Wang (266175), Jian-Xin Wang, Li-Ya Niu, Li-Ya Niu (1634431), Xin Zhu (427705), Qing-Zheng Yang (1273215), Xin Zhu, Qing-Zheng Yang   +7 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Aggregation-induced emission photosensitizers: from molecular design to photodynamic therapy

, 2020
Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment option for cancers and other diseases. The key factor that determines the effectiveness of PDT is the photosensitizers (PSs).
Xiaoding Lou (1406035), Xia Wu (203682), Siyang Ding (9488540), Fan Xia (219575), Yuning Hong (9484979), Shixuan Wang (136189), Jun Dai (435229)   +6 more
core   +1 more source