Results 221 to 230 of about 1,974,144 (325)

Ganglioside GM1 slows down Aβ(1-42) aggregation by a primary nucleation inhibitory mechanism that is modulated by sphingomyelin and cholesterol. [PDF]

Commun Chem
Sasanian N, Halipi V, Sjögren M, Bengtsson J, Bernson D, Esbjörner EK.   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Targeting Integrin β3: novel antiplatelet lignans 6'-Hydroxyjusticidin B and Neojusticin A from Justicia procumbens unveiled via multi-omics and biophysical validation. [PDF]

Nat Prod Bioprospect
Xiang M, Wu S, Mei H, Zheng X, Wang C.
europepmc   +1 more source

Hierarchical structuring of Cultural Heritage objects within large aggregations

, 2013
Shenghui Wang, Antoine Isaac, Valentine Charles, Rob Koopman, Anthi Agoropoulou, Titia van der Werf   +5 more
openalex   +1 more source

Aggregate formation in soil. 2. Influence of various carbohydrates and proteins on aggregation of soil particles [PDF]

, 1948
Michael Geoghegan, R. C. Brian
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Privacy-preserving federated credit risk models: evaluating differential privacy and homomorphic encryption techniques. [PDF]

Sci Rep
Naresh VS, Ayyappa D.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Literature review of the use of Qualitative Behaviour Assessment with a fixed list of terms. [PDF]

Front Vet Sci
Czycholl I, Skovlund CR, Forkman B.
europepmc   +1 more source

Kinetic investigation of calcium-induced Sorcin aggregation by stopped-flow light scattering [PDF]

Qiushi Ye, Kathleen Joyce Carillo, Nicolas Delaeter, Lei Zhang, Jaekyun Jeon, Yanxin Liu   +5 more
openalex   +1 more source