Results 61 to 70 of about 828,669 (295)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Multiple Attribute Decision Making Based on Hesitant Fuzzy Einstein Geometric Aggregation Operators
Journal of Applied Mathematics, 2014 We first define an accuracy function of hesitant fuzzy elements (HFEs) and develop a new method to compare two HFEs. Then, based on Einstein operators, we give some new operational laws on HFEs and some desirable properties of these operations.
Xiaoqiang Zhou, Qingguo Li
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Scientific ReportsA complex Polytopic fuzzy set (CPoFS) extends a Polytopic fuzzy set (PoFS) by handling vagueness with degrees that range from real numbers to complex numbers within the unit disc. This extension allows for a more nuanced representation of uncertainty. In
Khaista Rahman, Mohammad Khishe
doaj +1 more source
IEEE Access, 2020 Some q-rung orthopair fuzzy Bonferroni mean Dombi aggregation operators have been developed based on the Bonferroni mean, Dombi T-norm and T-conorm in q-rung orthopair fuzzy environment.
Wei Yang, Yongfeng Pang
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A New Aggregation Operator Based on Uninorms in L*-Fuzzy Set
International Journal of Computational Intelligence Systems, 2020 In practical applications, some existing multi-attribute decision-making methods based on the L∗ fuzzy set theory suffer from a lot of shortcomings, namely, incorrect choice preference orders of alternatives are obtained in some cases.
Minxia Luo, Yue Zhang, Bei Liu
doaj +1 more source
Aggregation Operators and Quadric Hypersurfaces [PDF]
, 2013 Aggregation operators that are quadric hypersurfaces are studied. The interest lays in the fact that the most popular aggregation operators are indeed quadric hypersurfaces.
openaire +4 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source