Results 101 to 110 of about 135,667 (297)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Using fuzzy numbers and OWA operators in the weighted average and its application in decision making [PDF]
, 2009 Se presenta un nuevo método para tratar situaciones de incertidumbre en los que se utiliza el operador OWAWA (media ponderada – media ponderada ordenada). A este operador se le denomina operador OWAWA borroso (FOWAWA).
Casanovas Ramón, Montserrat +2 more
core
Aggregation Operators and Quadric Hypersurfaces [PDF]
, 2013 Aggregation operators that are quadric hypersurfaces are studied. The interest lays in the fact that the most popular aggregation operators are indeed quadric hypersurfaces.
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Spatial Aggregation: Theory and Applications
, 1996 Visual thinking plays an important role in scientific reasoning. Based on the research in automating diverse reasoning tasks about dynamical systems, nonlinear controllers, kinematic mechanisms, and fluid motion, we have identified a style of visual ...
Yip, K., Zhao, F.
core +4 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Group Decision-Making Approach without Weighted Aggregation Operators
Discrete Dynamics in Nature and Society, 2018 This paper introduces an approach for group decision-making problems (GDMP) without weighted aggregation operators. This approach is more suitable for scenarios with infinite number of individuals.
Min Jiang, Zhiqing Meng, Rui Shen
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Manipulation in Group Argument Evaluation. [PDF]
Given an argumentation framework and a group of agents, the individuals may have divergent opinions on the status of the arguments. If the group needsto reach a common position on the argumentation framework, the question is how the individual ...
Caminada, Martin +2 more
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source