Results 41 to 50 of about 12,668 (267)
Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
Challenges in Agile Software Maintenance for Local and Global Development: An Empirical Assessment
Information, 2023 Agile methods have gained wide popularity recently due to their characteristics in software development. Despite the success of agile methods in the software maintenance process, several challenges have been reported.
Mohammed Almashhadani +3 more
doaj +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Agile architecture in the digital era: Trends and practices [PDF]
Strategic Management, 2019 The speed of response to change and fluidity are key preconditions for the next generation of IT solutions in the digital world. We are witnessing a rather unimaginable expansion of the use of technology in everyday life, on the one hand, and a ...
Dragičević Zoran, Bošnjak Saša
doaj
A Systematic Review of SCRUM in Software Development
JOIV: International Journal on Informatics Visualization, 2019 Scrum is a part of agile software development which also called incremental software development model. Scrum methodology commonly used to overcome uncertain condition and tight deadline. Scrum consists of three roles, they are product owner, development
Eduard Pangestu Wonohardjo +2 more
doaj +1 more source
IEEE Access, 2020 Agile software development performance depends on active communication. Active communication is an arduous task when agile teams are geographically distributed.
Yehia Ibrahim Alzoubi, Asif Qumer Gill
doaj +1 more source
Functional and Non‐Functional Requirements in Agile Software Development [PDF]
, 2023 S. Saroja, S. Haseena
openalex +1 more source
Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces a novel metamaterial absorber integrating water as a lossy medium with patterned indium tin oxide (ITO) films to achieve simultaneous optical transparency and ultra‐wideband electromagnetic absorption over 0.52‐40 GHz. It effectively overcomes the limitations of conventional opaque and bulky shielding materials, offering a ...
Xiaojun Huang +5 more
wiley +1 more source