Results 41 to 50 of about 137,834 (292)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Serrodyne‐Enabled Dual Electro‐Optic Comb Interferometry for High‐Precision Absolute Ranging and Integration‐Ready Metrology

Advanced Science, EarlyView.
A serrodyne‐modulated dual electro‐optic comb interferometer is presented that achieves sub‐nanometer precision in absolute distance measurements. The system also supports diverse applications such as depth imaging and vibration sensing. With features of low RF power, wide frequency‐shifting range, and full integration potential, the system offers a ...
Xiaoyang Guo, Xusheng Yang, Jiawen Zhi, Chenggang Shao, Hanzhong Wu   +4 more
wiley   +1 more source

Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing

Advanced Science, EarlyView.
A next‐generation cytosine base editor (zTadCBE) and other variants are developed by combining the high‐efficiency (TadCBEa) and low‐indel (TadCBEMax) architectures, followed by the introduction of zebrafish‐optimized mutations (V82S, Q154R) in the TadA domain.
Wei Qin, Sheng‐Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K. Varshney   +7 more
wiley   +1 more source

Guidelines Towards Better Participation of Older Adults in Software Development Processes using a new SPIRAL Method and Participatory Approach

, 2018
This paper presents a new method of engaging older participants in the process of application and IT solutions development for older adults for emerging IT and tech startups.
Aula Anne, Knapp Jake, Naumanen Minnamari, Orzeszek D., Sanders Elizabeth B-N, Schumacher Jens   +5 more
core   +1 more source

Maturity in Agile Software Development

Anais do XV Simpósio Brasileiro de Qualidade de Software (SBQS 2016), 2016
This paper summarizes the main objectives, research approach, and contributions of the doctoral dissertation named as “Maturity in Agile Software Development”. It was developed in the Graduate Program in Informatics of the Pontifical Catholic University of Parana, from 2013 to 2015.
Andreia Malucelli, Rafaela Mantovani Fontana, Sheila Reinehr   +2 more
openaire   +2 more sources

Rapid and Ultra‐Sensitive SARS‐CoV‐2 Subgenomic RNA Detection Using Single‐Molecule With a Large Transistor‐SiMoT Bioelectronic Platform

Advanced Electronic Materials, EarlyView.
The single‐molecule with a large transistor‐SiMoT is proposed for the detection of the subgenomic RNA of SARS‐CoV‐2, achieving a diagnostic sensitivity of 98.0% and a specificity of 87.8%. The SiMoT technology, currently at TRL‐5, is suitable for point‐of‐care settings and delivers the result to the end user in 30 min.
Eleonora Macchia, Anna Maria D'Erchia, Mariapia Caputo, Angelica Bianco, Claudia Leoni, Francesca Intranuovo, Cecilia Scandurra, Lucia Sarcina, Cinzia Di Franco, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi, Graziano Pesole   +12 more
wiley   +1 more source

Comparative Study on Agile software development methodologies [PDF]

, 2013
Today-s business environment is very much dynamic, and organisations are constantly changing their software requirements to adjust with new environment.
Hossain, Dr Syed Akhter, Moniruzzaman, A B M   +1 more
core   +2 more sources

Agile Software Development in Practice [PDF]

, 2014
Agile software development methods have been around since the mid 1990s. Over these years, teams have evolved the specific software development practices used. Aims: The goal of this paper is to provide a view of the agile practices used by new teams, and the relationship between the practices used, project outcomes, and the agile principles.
Maureen Doyle, Laurie Williams, Mike Cohn, Kenneth S. Rubin   +3 more
openaire   +2 more sources

Direct‐Write Printed Contacts to Layered and 2D Materials

Advanced Electronic Materials, EarlyView.
It is demonstrated that direct‐write printing is a viable method to fabricate devices on different 2D and layered materials yields Ohmic contacts in a single step, as compared to multi‐step lithography processes which often yield poor contacts. Printed devices perform exceedingly well with gating, temperature cycling, and in magnetic fields.
Sharadh Jois, Erica Lee, Philip Li, Tsegereda Esatu, Jason Fleischer, Edwin Quinn, Genda Gu, Vadym Kulichenko, Luis Balicas, Son T. Le, Samuel W. LaGasse, Aubrey T. Hanbicki, Adam L. Friedman   +12 more
wiley   +1 more source

Studying Attitudes and Social Norms in Agile Software Development

, 2018
The purpose of this paper is to review research on attitudes and social norms and connect it to the agile software development context. Furthermore, I propose additional theories from social psychology (mainly the theory of planned behavior and using the
Gren, Lucas
core   +1 more source