Results 91 to 100 of about 2,225,048 (294)
On the heat of the Sun, and on the Temperatures and relative ages of the Stars and Nebulae. [PDF]
, 1899 T. J. J. See
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Improving Lives through Evidence-Based Health Promotion Programs: A National Priority
Frontiers in Public Health, 2015 Richard eBirkel +9 more
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Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
The Scientific World Journal, 2010 Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition.
Emanuele Marzetti +6 more
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A CASE OF LYMPHADENOMA INVOLVING THE STOMACH IN A CHILD AGED EIGHTEEN MONTHS COMPLICATED BY RICKETS AND CLOSELY SIMULATING LEUKÆMIA. [PDF]
, 1898 Humphry Rolleston, Arthur Latham
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Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Rhinolith, weighing seventy‐six grains, in a child ten years of age [PDF]
, 1896 J. A. Stucky
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Aging and diet alter the protein ubiquitylation landscape in the mouse brain
Nature CommunicationsPost-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs remains unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in the mouse
Antonio Marino +7 more
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