Results 91 to 100 of about 2,198,545 (274)
Quantitative mapping of proteasome interactomes and substrates using ProteasomeID
eLifeProteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer.
Aleksandar Bartolome +11 more
doaj +1 more source
Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
The Scientific World Journal, 2010 Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition.
Emanuele Marzetti +6 more
doaj +1 more source
Age-Associated Disorders As A Proxy Measure Of Biological Age: Findings From the NLTCS Data [PDF]
arXiv, 2005 Background: The relative contribution of different aging-associated processes to the age phenotype may differ among individuals, creating variability in aging manifestations among age-peers. Capturing this variability can significantly advance understanding the aging and mortality.
arxiv
Age relation of the pre-Cambrian rocks in the Catoctin Mountain-Blue Ridge and Mount Rogers anticlinoria in Virginia [PDF]
, 1939 A. I. JONAS, George W. Stose
openalex +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Dynamic networks reveal key players in aging [PDF]
arXiv, 2013 Motivation: Since susceptibility to diseases increases with age, studying aging gains importance. Analyses of gene expression or sequence data, which have been indispensable for investigating aging, have been limited to studying genes and their protein products in isolation, ignoring their connectivities.
arxiv
Reconciliations of Christianity and ScienceChristian Faith in an Age of Science. William North Rice [PDF]
, 1904 Cory R. Barnes
openalex +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Collection de Documents pour l'Histoire religieuse et littéraire du Moyen Age. Paul Sabatier [PDF]
, 1901 Franklin Johnson
openalex +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source