Results 191 to 200 of about 2,198,545 (274)

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Immune-aging at diagnosis determines T-cell recovery in childhood leukemia survivors. [PDF]

NPJ Aging
Dhodapkar KM, Castellino S, Kapadia S, Azeem MI, Horvat A, Lawrence T, DeRyckere D, Dhodapkar MV.   +7 more
europepmc   +1 more source

The Age of the Earth1 [PDF]

, 1895
John Perry
openalex   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Frontiers in Age-Related Diseases and Nutritional Interventions. [PDF]

Nutrients
Yu C, Qiu L, Wang X.
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Editorial: Mechanistic theories of aging. [PDF]

Front Aging
Tower J.
europepmc   +1 more source

Art. XIV.—Brief Notes on the Age and Authenticity of the Works of Âryabhaṭa, Varâhamihira, Brahmagupta, Bhaṭṭotpala, and Bhâskarâchârya [PDF]

Bhâu Dâjî
openalex   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Endometrial aging is accompanied by H3K27ac and PGR loss. [PDF]

Nat Aging
Wang Y, Zhou P, Shan H, Liu X, Cheng M, Ye Z, Chen X, Liao B, Peng T, Xiao C, Huang Z, Dong Y, Yu Y, Pan H, Li R.   +14 more
europepmc   +1 more source