Results 181 to 190 of about 1,760,131 (304)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Role of EVs in the Aging Hematopoietic System. [PDF]

Aging Cell
Kosebent EG, Havranek N, Kollmann K, Kirschner K, Doma E, Gupta K.   +5 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Accelerated Aging and Risk of Subsequent Neoplasms in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study. [PDF]

Cancer Epidemiol Biomarkers Prev
Berkman AM, Bhatia S, Mirzaei S, Li K, Im C, Leisenring WM, Williams AM, Esbenshade AJ, Hayek S, Chow EJ, Turcotte LM, Neglia JP, Arnold MA, Srivastava D, Nolan VG, Ness KK, Hudson MM, Armstrong GT.   +17 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Degradation Mechanisms of Epoxy Coatings and Their Adhesion to Cementitious Substrates Under Intense Ultraviolet Radiation. [PDF]

Polymers (Basel)
Sun B, Xie C, Ma W, Liu C.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms of Brain Aging and Their Links to Alzheimer's and Parkinson's Disease Pathology. [PDF]

Int J Mol Sci
Yi H, Qin H, Goon JA, Makpol S, Tan JK.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Association of Environmental Factors and Aging Levels Under Different Urbanization Levels in China. [PDF]

Geohealth
Zheng Z, Liu Y, Zang J, Xu H, Lu K, Ban J, Wang Q.   +6 more
europepmc   +1 more source