Results 161 to 170 of about 1,517,822 (306)

An Aging Clock Based on Immune Repertoire Features: COVID-19 Accelerates Aging. [PDF]

Aging Cell
Gao X, Li SJ, Li J, Wang ZH, Zeng LT, Ma YQ, Dang YM, Zhang YM, Liu HL, Zhang LQ, Pang J, Cui J, Zhang TM, Cai JP.   +13 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

[LGTB Friendly Senior Housing Metric Survey with Introduction Letter] [PDF]

LGTB Friendly Senior Housing Metric Survey with introduction letter from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core  

The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience. [PDF]

Diabetes Care
Espeland MA, Semelka CT, Kritchevsky SB, Evans JK, Newman AB.   +4 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice. [PDF]

Aging Cell
Zhang X, Tripathi M, Goh CT, Chan CS, Boelen A, Yen PM, Singh BK, Bruinstroop E.   +7 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Podocyte mPGES-2 Determines Renal Aging and Contributes to Senile Osteoporosis. [PDF]

Aging Cell
Zhong D, Hao C, Li M, Liu J, Xu Z, Zhou J, Zhao L, Ni S, Hu Z, Sun Y, Zou Y, Sun D, Guo H, Jia Z, Guo D, Cao JL, Sun Y.   +16 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source