Results 171 to 180 of about 1,760,131 (304)

Nanoparticle-Based Tools to Study Hallmarks of Aging at the Molecular Level. [PDF]

Int J Nanomedicine
Yao S, Shen G, Zhao J.
europepmc   +1 more source

Other title: Update on Osawatomie State Hospital Provisos and Larned State Hospital Certification

, 2018
application/pdf; "January 18, 2018."; Presentation before the Kansas Legislature, House Appropriations Committee, by the Kansas Department for Aging and Disability Services.Presentation concerning two provisos set up by the 2017 Legislature ...
Kansas. Department for Aging and Disability Services.
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives. [PDF]

Geriatrics (Basel)
Morén C, Pérez-Toribio A, Rubio-Contreras E, Álvaro P, Rosa A, Pedregosa S.   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Salt Spray Aging Behavior and Life Prediction of Thermoplastic Carbon Fiber-Reinforced Poly(methyl methacrylate) Composites. [PDF]

Materials (Basel)
Guo X, Li S, Li G, Wang Y, Zhang J.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF-3α-BNIP3 Axis. [PDF]

Aging Cell
Jin N, Zhou L, Gui H, Tang J, Huang X, Wang W, Jin G, Cheng H, Liang Y, Geng X, Peng Z, Zhao H, Liu Z, Xie J.   +13 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Effect of Polyphosphoric Acid on the Coupled Aging Behavior of SBR-Modified Asphalt Under Intense UV Radiation and Large Temperature Differences. [PDF]

Polymers (Basel)
Xu Y, Tian B, Cao X, Wang J.
europepmc   +1 more source