Results 231 to 240 of about 4,011,650 (333)

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Psychological resources and illness recovery in later life: independent associations of positive mental health and attitudes to aging. [PDF]

BMC Geriatr
Wu J, Li Y, Chao Q.
europepmc   +1 more source

Recent discovery of rocks of the age of the Trenton Formation at Akpatok Island, Ungava Bay, Ungava [PDF]

, 1899
J. F. Whiteaves
openalex   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

The Ambiguous Role of HMGB1 Across the Hallmarks of Aging: A Narrative Review. [PDF]

Clin Interv Aging
Ning M, Liang Y, Zhang L, Wang F, He L.
europepmc   +1 more source

Aging

Experimental Animals, 2020
openaire   +3 more sources

Age Integration or Age Conflict as Society Ages? [PDF]

The Gerontologist, 2000
openaire   +3 more sources

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy. [PDF]

Mol Cancer
Yang H, Liu D, Qiu L, Wang R, Zhang C, Yu D, Zhong Q, Yuki N, Song Z, Zhu T, Ju H, Hong W, Zhu J.   +12 more
europepmc   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source