Results 31 to 40 of about 12,311,713 (381)

Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]

, 2016
There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M., McGuinness, Dagmara, Payne, Anthony P., Shields, Paul G.   +3 more
core   +2 more sources

The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population

Lipids in Health and Disease, 2018
Background Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases.
Meng-yun Cai, Jie Cheng, Meng-yuan Zhou, Li-li Liang, Si-min Lian, Xiao-shan Xie, Shun Xu, Xinguang Liu, Xing-dong Xiong   +8 more
doaj   +1 more source

Ethical perspectives on advances in biogerontology [PDF]

, 2019
Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four.
Archard, David, Au, Derrick, Bergstresser, Sara, Erler, Alexandre, Kwok, Timothy, Newman, John, Tong, Raymond, Walker, Tom, Woo, Jean   +8 more
core   +1 more source

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

Physiological Reviews, 2019
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which require costly hospitalization and extended rehabilitation.
L. Larsson, H. Degens, Meishan Li, L. Salviati, Young Il Lee, W. Thompson, J. Kirkland, M. Sandri   +7 more
semanticscholar   +1 more source

A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance

BMC Genomics, 2022
Background Organisms in the wild can acquire disease- and stress-resistance traits that outstrip the programs endogenous to humans. Finding the molecular basis of such natural resistance characters is a key goal of evolutionary genetics.
Wenke Wang, Anna G. Flury, Andrew T. Rodriguez, Jennifer L. Garrison, Rachel B. Brem   +4 more
doaj   +1 more source

Aging phenomena in polystyrene thin films

, 2007
The aging behavior is investigated for thin films of atactic polystyrene through measurements of complex electric capacitance. During isothermal aging process the real part of the electric capacitance increases with aging time, while the imaginary part ...
Fukao, Koji, Koizumi, Hiroki
core   +1 more source

Mitochondrial Dysfunction in Aging and Diseases of Aging. [PDF]

, 2019
Mitochondria have been increasingly recognized as the important players in the aging process [...]
Haas, Richard H
core   +2 more sources

The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls

BMC Geriatrics, 2018
Background Peripheral sensory loss is considered one of many risk factors for gait impairments and falls in older adults, yet no prospective studies have examined changes in touch sensation in the foot over time and their relationship to mobility and ...
Lewis A. Lipsitz, Brad Manor, Daniel Habtemariam, Ikechukwu Iloputaife, Junhong Zhou, Thomas G. Travison   +5 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Aging cellular networks: chaperones as major participants

, 2006
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston, Barabasi, Blais, Borodina, C. Sőti, Chan, Cherian, Cowen, Csermely, Csermely, Csermely, Csermely, Donaldson, Dorogovtsev, Dukan, Fares, Ferrarini, Gavin, Goldberger, Hayflick, He, Herndon, Heydari, Himmelstein, Imai, Irish, Macario, Morimoto, Mukai, Nardai, Nardai, Nollen, P. Csermely, Paulsson, Promislow, Pál, Queitsch, Rual, Rutherford, Schwarzer, Song, Stadtman, Stelzl, Sőti, Sőti, Sőti, Sőti, von Mering, Werner-Washburne, Westerheide, White, Yam, Young, Young, Zhao, Zhu, Zou   +56 more
core   +1 more source