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Implementation of Aging Mechanism Analysis and Prediction for XILINX 7-Series FPGAs with a 28-nm Process [PDF]

open access: yesSensors, 2022
Commercial off-the-shelf (COTS) field-programmable gate arrays (FPGAs) with a 28-nm process have become popular devices for computing systems. Although current generation FPGAs have advantages over previous models, the phenomenon of circuit aging has ...
Zeyu Li   +4 more
doaj   +2 more sources

Biosynthetic Mechanisms and Biological Significance of Glycerol Phosphate-Containing Glycan in Mammals

open access: yesMolecules, 2021
Bacteria contain glycerol phosphate (GroP)-containing glycans, which are important constituents of cell-surface glycopolymers such as the teichoic acids of Gram-positive bacterial cell walls.
Rieko Imae, Hiroshi Manya, Tamao Endo
doaj   +1 more source

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

open access: yesCell Death and Disease, 2022
Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes to the development of tumor suppressive immune microenvironment and
Lin Zhao   +6 more
doaj   +1 more source

Aging mechanisms [PDF]

open access: yesProceedings of the National Academy of Sciences, 2000
Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. However, we have recently started to learn the molecular mechanisms that control aging.
F.Ishikawa, Y.Takahashi, M.Kuro-o
openaire   +2 more sources

Diagnostic potential of serum extracellular vesicles expressing prostate-specific membrane antigen in urologic malignancies

open access: yesScientific Reports, 2021
We aimed to develop a sandwich ELISA to detect prostate-specific membrane antigen (PSMA) on small extracellular vesicles (EVs) using T-cell immunoglobulin domain and mucin domain-containing protein 4 (Tim4) as a capture molecule for EVs and to evaluate ...
Kyojiro Kawakami   +12 more
doaj   +1 more source

Mechanisms of ovarian aging [PDF]

open access: yesReproduction, 2021
Ovarian aging in women correlates with the progressive loss of both the number and quality of oocytes. When these processes occur early or are accelerated, their clinical correlates are diminished ovarian reserve and/or premature ovarian insufficiency.
Selena U Park   +2 more
openaire   +2 more sources

C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]

open access: yes, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper   +38 more
core   +16 more sources

Comprehensive Study of Failure Mechanisms of Field-Aged Automotive Lead Batteries

open access: yesBatteries, 2023
Modern vehicles have increasing safety requirements and a need for reliable low-voltage power supply in their on-board power supply systems. Understanding the causes and probabilities of failures in a 12 V power supply is crucial.
Rafael Conradt   +6 more
doaj   +1 more source

Brain aging mechanisms with mechanical manifestations

open access: yesMechanisms of Ageing and Development, 2021
Brain aging is a complex process that affects everything from the subcellular to the organ level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily characterized by brain volume loss, cortical thinning, white matter degradation, loss of gyrification, and ventricular enlargement.
Blinkouskaya, Y   +4 more
openaire   +2 more sources

The Role of APP O-Glycosylation in Alzheimer’s Disease

open access: yesBiomolecules, 2020
The number of people with dementia is increasing rapidly due to the increase in the aging population. Alzheimer’s disease (AD) is a type of neurodegenerative dementia caused by the accumulation of abnormal proteins.
Keiko Akasaka-Manya, Hiroshi Manya
doaj   +1 more source

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