Results 171 to 180 of about 981,146 (304)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Hydroxychloroquine’s diverse targets: a new frontier in precision medicine

Frontiers in Immunology
Bin Du, Leqi Li, Jingjing Li, Yiping Liu, Pu Wang   +4 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Adsorption of Cs Ions in Hydroxy-Al Interlayered Clay Minerals and the Aging Mechanism. [PDF]

Langmuir
Sakuma H, Tamura K, Suehara S, Hashi K.
europepmc   +1 more source

Aging—mechanisms, models, and translation [PDF]

Zeitschrift für Gerontologie und Geriatrie, 2013
A, Stolzing, J, Haendeler
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Understanding Aging Mechanism of SBS/CR Composite Modified Asphalt Based on ATR-FTIR: Chemical Degradation and Aging Deterioration. [PDF]

Materials (Basel)
Li L, Yang C, Li L, Quan W, Wang Y, Tan Y, Li Y, Zhang Z.   +7 more
europepmc   +1 more source

Aging Mechanism and Rejuvenating Possibility of SBS Copolymers in Asphalt Binders. [PDF]

Polymers (Basel), 2020
Wang F, Zhang L, Zhang X, Li H, Wu S.
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Interfacial Evolution and Accelerated Aging Mechanism for LiFePO₄/Graphite Pouch Batteries Under Multi-Step Indirect Activation. [PDF]

Nanomicro Lett
Liu Y, Dong J, Zhou J, Guan Y, Wei Y, Zhao J, Liang J, Shi X, Yan K, Lu Y, Li N, Su Y, Wu F, Chen L.   +13 more
europepmc   +1 more source