Results 41 to 50 of about 290,636 (313)

Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice [PDF]

, 2007
Glucocorticoids are pivotal in the maintenance of memory and cognitive functions as well as other essential physiological processes including energy metabolism, stress responses, and cell proliferation.
Brownstein, D., Yau, Joyce L. W.; id_orcid, Seckl, J.R., Cobb, S., Morris, RGM, Mcnair, Kara, Brownstein, David, Morton, Nik, Yau, JLW, Brownstein, D, Mullins, JJ, Hibberd, C., Morton, N., McNair, Kara M., Cobb, Stuart, Seckl, JR, Morris, R.G.M., Hibberd, C, McNair, KM, Seckl, Jonathan R., Mullins, J.J., Morton, N, Cobb, S, Hibberd, Carina, Morris, Richard G. M., Mullins, John J., Noble, J, Yau, J.L.W., Noble, June, Noble, J.   +29 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

HIV Diagnosis Disclosure: Stigma Management and Stigma Resistance

, 2010
This article reports diagnosis disclosure decision comments arising serendipitously in five focus group discussions with 34 HIV-infected New Yorkers over age 50.
Shippy, R Andrew, Poindexter, Cynthia Cannon   +1 more
core   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Elevated mutagenesis does not explain the increased frequency of antibiotic resistant mutants in starved aging colonies. [PDF]

PLoS Genetics, 2013
The frequency of mutants resistant to the antibiotic rifampicin has been shown to increase in aging (starved), compared to young colonies of Escherichia coli.
Sophia Katz, Ruth Hershberg
doaj   +1 more source

Aging process and strengthening mechanism of Cu–Cr–Ni alloy with superior stress relaxation resistance

Journal of Materials Research and Technology, 2022
With the development trend of connectors to high-current and high-temperature service, copper alloy connectors are required to have superior stress relaxation resistance.
Guojie Wang, Haitao Liu, Kexing Song, Yanjun Zhou, Chu Cheng, Huiwen Guo, Yingang Guo, Jing Tian   +7 more
doaj   +1 more source

Aging effect in nasal resistance.

Nippon Jibiinkoka Gakkai Kaiho, 1984
5歳から84歳までの鼻疾患,呼吸器疾患のない男女501例について,一方向流によるpassive anterior法にて鼻腔抵抗の測定を行い,5歳から16歳までの各年齢および15歳以上の6つの年齢群ごとの測定値を示し,年齢と鼻腔抵抗の変化につき検討を加え,次のような結果を得た.1) 5歳から16歳までの抵抗の変化は,a) 8歳までの抵抗の高い時期,b) それに続き11歳頃までの比較的急激に抵抗が低下する時期,およびc) それ以後の抵抗の変動が認められる時期の3つに分けられる.a)においてはアデノイドの存在が,b)においては鼻腔の大きさの増大とアデノイドの消退が,c)においては鼻腔や鼻甲介の発育の不均衡と自律神経系の影響が考えられた.2) 20歳以後の抵抗の変化には次の2つの特徴がみられた.a ...
openaire   +3 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Enhanced Ozone Aging Resistance of Natural Rubber with 2-Mercaptobenzothiazole as the Constant-Viscosity Agent

Journal of Chemistry, 2023
For the actual storage and serving, a phenomenon of hardening and cracking always occurs in the natural rubber (NR), which sharply reduces the mechanical performance and hinders the further application of NR.
Juan Zhou, Peng Deng, Hongxing Gui, Junxiao Xu, Jianhe Liao, Aiwu Ding   +5 more
doaj   +1 more source