Results 61 to 70 of about 2,734,594 (261)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Aging connection (Columbus, Ohio : Online)

, 2006
Monthly; Electronic coverage as of May 22, 2007: Mar. 2006-; Description based on Mar. 2006; title from Web page (viewed on May 22, 2007).; Harvested from the web on 5/22/07June 2006, Ohio Leads Nation in Senior Services Levy Revenue. Department of Aging
Ohio. Dept. of Aging
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Effect of Creep Aging Process on Microstructures and Properties of the Retrogressed Al-Zn-Mg-Cu Alloy

Metals, 2016
The creep aging behaviors of retrogressed Al-Zn-Mg-Cu alloy were studied by uniaxial tensile creep tests at 140 °C. The effects of creep aging time and applied stress on microstructures and properties of the studied alloy were investigated by using ...
Yongqian Xu, Lihua Zhan
doaj   +1 more source

Antibiotic resistance and the golden age of microbiology [PDF]

Upsala Journal of Medical Sciences, 2014
The ability of micro-organisms to develop resistance to the action of inhibitors has been known since the discovery of antimicrobial agents. The first reports were concerned with agents such as Salvarsan and Prontosil in the early 1900s; the phenomenon of ‘fastness’ to these agents was observed frequently during treatment with the drugs.
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Design of Polyurethane Pervious Concrete and Weather Resistance

Journal of Applied Science and Engineering
Polyurethane pervious concrete has gained significant attention in urban pavement applications due to its rapid construction, wide color range, and improved comfort underfoot. This material offers a promising alternative for sustainable and aesthetically
Mingming Dong, Xianwei Ma, Wenbin Zhang
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Scabies in the age of increasing drug resistance

PLOS Neglected Tropical Diseases, 2017
Scabies is an infestation of the skin by the mite Sarcoptes scabiei. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. This paper will review the mechanisms of resistance proposed
Khalil, Samar, Abbas, Ossama, Kibbi, Abdul-Ghani, Kurban, Mazen   +3 more
openaire   +5 more sources