Results 81 to 90 of about 290,636 (313)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

An alternative methodology to predict aging effects on the mechanical properties of glass fiber reinforced cement (GRC)

, 2012
The effect of three different aging methods (immersion in hot water, freeze–thaw cycles and wet–dry cycles) on the mechanical properties of GRC were studied and compared.
Alejandro Enfedaque, Laura Sánchez Paradela, Vicente Sánchez-Gálvez, Enfedaque Díaz, Alejandro, Sanchez Galvez, Vicente, Sanchez Paradela, Laura   +5 more
core   +1 more source

Intrinsic aerobic capacity sets a divide for aging and longevity [PDF]

, 2011
<p><b>Rationale:</b> Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease.
Kemi, Ole J., Peter M. Abadir, Natale Rolim, Godfrey L. Smith, Wisløff, Ulrik, Bijma, P., Wisløff, Helene, van Grevenhof, Elizabeth M., Steven L. Britton, Ellingsen, Øyvind, Burant, Charles F., Leng, Sean X., Qi, Nathan, Lori J. Gilligan, Gilligan, L.J., Lauren Gerard Koch, Qi, N., Piter Bijma, John E. Wilkinson, van Grevenhof, E.M., Ole J. Kemi, Helene Wisløff, Rolim, Natale, Kemi, O.J., Bijma, Piter, Nathan Qi, Sean X. Leng, Gilligan, Lori J., Smith, Godfrey L., Koch, G., Wilkinson, J.E., Morten A. Høydal, Ulrik Wisløff, Koch, Lauren Gerard, Høydal, Morten A., Grevenhof, E.M., van, Britton, Steven L., Leng, S.X., Wilkinson, John E., Elizabeth M. van Grevenhof, Charles F. Burant, Abadir, Peter M., Øyvind Ellingsen   +42 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training

, 2008
Purpose of Review: Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging.
Hayes, Alan, Cribb, Paul J
core  

Expert Consensus on Prevention and Treatment of Aging-Related Gonadal Dysfunction [PDF]

Aging -related hypogonadism involves complex mechanisms in humans, predominantly relating to the decline of multiple hormones and senile gonads. Late -onset hypogonadism (LOH) and erectile dysfunction (ED) are the main manifestations in men, while ...
Wen, Junping, Yan, Zhaoli, Mao, Jiangfeng, Han, Qin, Jin, Kunlin, Caruso, Calogero, Jiang, Sheng, Wu, Xueyan, Zhao, Robert Chunhua, Min, Kyung-Jin, Tian, Long, Deng, Shan, Huang, Boxian, Ma, Li, Stambler, Ilia, Wang, Xi, Su, Huanxing   +16 more
core   +1 more source

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance [PDF]

, 2020
It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions can be reversed. How the interface of immunity and metabolism impinges upon the diabetes pandemic is largely unknown.
He, Ming, Mu, Wei-Chieh, Wang, Li, Luo, Hanzhi, Tan, Mingdian, Wu, Hao, Qiao, Qi, Ohkubo, Rika, Zhao, Shimin, Chiang, Hou-Hsien, Zheng, Zhifang, Chen, Danica   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Design of Polyurethane Pervious Concrete and Weather Resistance

Journal of Applied Science and Engineering
Polyurethane pervious concrete has gained significant attention in urban pavement applications due to its rapid construction, wide color range, and improved comfort underfoot. This material offers a promising alternative for sustainable and aesthetically
Mingming Dong, Xianwei Ma, Wenbin Zhang
doaj   +1 more source