Results 91 to 100 of about 290,636 (313)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Insulin and brain aging

, 2017
The world’s population is living much longer than in the past. It is crucial to find as many pathological factors that deteriorate the health condition and well-being of elderly people as possible.
Agnieszka Baranowska-Bik, Wojciech Bik
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA). [Elektronisk resurs]

, 2014
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early ...
Nilsson, Peter,, Lund University.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

, 2006
Background The provision of stress resistance diverts resources from development and reproduction and must therefore be tightly regulated. In Caenorhabditis elegans, the switch to increased stress resistance to promote survival through periods of ...
Halstead, JR, Weinkove David, Gems, D, Gems David, Divecha Nullin, Weinkove, DH, Gems, D., Divecha, N., Weinkove, D., Halstead, J. R., Halstead Jonathan R, Divecha, N, Halstead, J.R.   +12 more
core   +1 more source

Effects of three types of exercise interventions on healthy old adults’ gait speed: A systematic review and meta-analysis [PDF]

, 2015
Background Habitual walking speed predicts many clinical conditions later in life, but it declines with age. However, which particular exercise intervention can minimize the age-related gait speed loss is unclear.
Lesinski, M., Hortobágyi, Tibor, Lesinski, Melanie, Lesinski, Melanie (Dr.), Tibor Hortobágyi, Martijn Gäbler, Jessie M. VanSwearingen, Hortobagyi, Tibor; id_orcid, Hortobágyi, Tibor (Prof. Dr.), Granacher, Urs, Van Swearingen, Jessie, VanSwearingen, Jessie M., Melanie Lesinski, Urs Granacher, Malatesta, D., Granacher, U., Gäbler, M., Granacher, Urs (Prof. Dr.), Hortobágyi, T., Gäbler, Martijn, VanSwearingen, J.M., Malatesta, Davide, Davide Malatesta   +22 more
core   +1 more source

Synergistic aging resistance of calcium sulfate whiskers and polyurethane in asphalt binders: Microscale mechanisms and rheological perspectives

Case Studies in Construction Materials
Polyurethane is commonly used to modify asphalt for improved strength and toughness, while it is prone to degradation from thermal oxidative and ultraviolet aging during service.
Guojing Huang, Fusen Zheng, Jiupeng Zhang, Xiaoqian Wang, Zikai Xu, Qinshi Hu, Yinzhang He, Xiang Yu, Mingliang Zhang, Lei Lyu, Jianzhong Pei   +10 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals

, 2018
The process of aging is determined by various genetic and environmental factors. Aging is associated with increased oxidative stress that alters cellular chromatin structure, DNA methylation with histone modifications.
Ian James Martins
core   +1 more source