Results 101 to 110 of about 290,636 (313)

Wear And Aging Of Peek, Zirconia, And Co-Cr Crowns

International Dental Journal
Aim or purpose: To compare the wear resistance, fracture resistance before and after aging, and displacement resistance of full crowns made from PEEK, cobalt-chromium alloy, and zirconia, providing a theoretical basis for PEEK’s application in crown ...
Shuo Yang, Yu Sun
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of thermal aging conditions on the corrosion properties and hardness of a duplex stainless steel

Materials Research, 2010
The corrosion properties of a 22.5 wt. (%) Cr duplex stainless steel were investigated after long-term aging of 3000, 5000 and 7000 hours at 300 and 400 ºC. The corrosion resistance was measured based on mass loss in a FeCl3 10 wt.
José Eduardo May, Carlos Alberto Caldas de Souza, Pedro Augusto de Paula Nascente, Paulo Soares, Carlos Mauricio Lepienski, Sebastião Elias Kuri   +5 more
doaj   +1 more source

Age of No Resistance

Contemporary societies increasingly organize human life around the systematic reduction of discomfort. Across technology, ethics, healthcare, and governance, resistance is treated as a design flaw to be minimized rather than as a constitutive condition of human existence.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Defining anabolic resistance: Implications for delivery of clinical care nutrition

, 2018
Purpose of review Skeletal muscle mass with aging, during critical care, and following critical care is a determinant of quality of life and survival. In this review, we discuss the mechanisms that underpin skeletal muscle atrophy and recommendations to ...
Traylor, Daniel A., Daniel A. Traylor, Peter J.M. Weijs, Stuart M. Phillips, Phillips, Stuart M., Weijs, Peter J.M., Traylor, Daniel, Philips, Stuart, Robert W. Morton, Morton, Robert W., Morton, Robert, Weijs, Peter   +11 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging

, 2017
Aging causes a general decline in cellular metabolic activity, and function in different tissues and whole body homeostasis. However, the understanding about the metabolomic and autophagy changes in skeletal muscle and heart during aging is still limited.
Salmon, Adam B., Jin Zhou, Shu Yun Chong, Brijesh K. Singh, Yen, Paul M., Sinha, Rohit A., Paul M. Yen, Andrea Lim, Lim, Andrea, Zhou, Jin, Rohit A. Sinha, Adam B. Salmon, Singh, Brijesh K., Chong, Shu Yun   +13 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Aging Resistance Evaluation of an Asphalt Mixture Modified with Zinc Oxide

Infrastructures
The phenomenon of the oxidation and aging of asphalt binders affects the strength and durability of asphalt mixtures in pavements. Several studies are trying to improve the resistance to this phenomenon by modifying the properties of the binders with ...
Hugo Alexander Rondón-Quintana, Carlos Alfonso Zafra-Mejía, Carlos Felipe Urazán-Bonells   +2 more
doaj   +1 more source