Results 111 to 120 of about 290,636 (313)

The age of no resistance

We live in a time where discomfort is increasingly treated as a design flaw. Friction is optimized away. Resistance is reframed as risk. Wherever strain appears, it is smoothed, mitigated, or eliminated in the name of care. At first glance, this seems humane. Yet something essential is lost when resistance disappears.
openaire   +1 more source

Scabies in the age of increasing drug resistance

PLOS Neglected Tropical Diseases, 2017
Scabies is an infestation of the skin by the mite Sarcoptes scabiei. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. This paper will review the mechanisms of resistance proposed
Khalil, Samar, Abbas, Ossama, Kibbi, Abdul-Ghani, Kurban, Mazen   +3 more
openaire   +5 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Metabolic syndrome, aging and involvement of oxidative stress

, 2015
The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions,
RODELLA, Luigi Fabrizio, REZZANI, Rita, BONOMINI, Francesca   +2 more
core   +1 more source

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression [PDF]

, 2019
Aging is characterized by a progressive loss of physiological integrity, while cancer represents one of the primary pathological factors that severely threaten human lifespan and healthspan.
Qixia Xu, Jianming Guo, Y. Eugene Chin, Liu Han, Xu, Jianmin, Liu Cao, Min Qian, Qian, Min, Yu Sun, Dexiang Zhu, Guo, Jianming, Long, Qilai, Boyi Zhang, Campisi, Judith, Cao, Liu, Xu, Qixia, Judith Campisi, Lam, Eric W-F, Eric W.‐F. Lam, Zhu, Dexiang, Han, Liu, Chin, Y Eugene, Lam, Eric W‐F, Jianmin Xu, Sun, Yu, Coppé, Jean‐Philippe, Coppé, Jean-Philippe, Fu, Da, Zhang, Boyi, Da Fu, Qilai Long, Jean‐Philippe Coppé   +31 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Age-Dependent Onset of Insulin Resistance in Insulin-Resistant Mice

Biological & Pharmaceutical Bulletin, 2015
We have previously isolated spontaneous insulin-resistant mice (ddY-H) and non-insulin-resistant mice (ddY-L) from ddY mice. In the present study, age-dependent onset of insulin resistance in obese ddY-H mice was investigated by comparing with lean ddY-L mice.
Ide, Naohito, Arisawa, Kasumi, Ogura, Kanami, Kagawa, Yoshiyuki, Maeda, Toshio   +4 more
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)

, 2012
The aim of the present study was to investigate the effect of aging on several parameters related to glucose homeostasis and insulin resistance in pancreas and how melatonin administration could affect these parameters.
Fernández-Tresguerres Hernández, Jesús Ángel, Cuesta Sancho, Sara, Rancán, Lisa, Vara Ameigeiras, Elena María, Kireev, Roman, García Martín, M. Cruz   +5 more
core   +1 more source

Optimal management of sarcopenia [PDF]

, 2010
Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of ...
Sumukadas, Deepa, Louise A Burton, Burton, Louise A., Deepa Sumukadas   +3 more
core   +1 more source